PMID- 11846872
OWN - NLM
STAT- MEDLINE
DCOM- 20020312
LR  - 20220317
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 12
IP  - 6
DP  - 2001 Dec
TI  - Cow's milk protein intolerance and chronic constipation in children.
PG  - 339-42
AB  - Cow's milk protein (CMP) allergy was investigated in 25 children (age-range 3 
      months to 11 years) with chronic constipation. A diagnosis of constipation was 
      made on the basis of a history of painful elimination of hard stools for at least 
      1 month, whether or not associated with a reduced frequency of stools or soiling. 
      The children were evaluated using clinical parameters and the following 
      laboratory tests: total serum immunoglobulin E (IgE); specific IgE 
      (radioallergosorbent test [RAST]) for whole cow's milk, alpha-lactoalbumin, 
      beta-lactoglobulin, and a food group; and skin-prick tests with whole milk, 
      alpha-lactoalbumin, beta-lactoglobulin, and casein. Following the evaluation, the 
      children were submitted to a CMP-free diet for a period of 4 weeks. In seven 
      patients (28%), constipation disappeared during the CMP-free diet and reappeared 
      within 48-72 h following challenge with cow's milk. In two infants a rectal 
      biopsy revealed allergic colitis and they therefore did not undergo the 
      challenge. High serum levels of total IgE were observed in five of the children 
      who showed a clinical improvement (71%), a positive skin-test in two (29%), and 
      detectable specific IgE in two (29%). These results suggest that CMP allergy or 
      intolerance should be considered as a cause of chronic refractory constipation in 
      children, although the underlying mechanism still require further investigation.
FAU - Daher, S
AU  - Daher S
AD  - Divisions of Allergy, Clinical Immunology and Rheumatology, UNIFESP - EPM, Sao 
      Paulo, SP, Brazil. silviadaher@hotmail.com
FAU - Tahan, S
AU  - Tahan S
FAU - Sole, D
AU  - Sole D
FAU - Naspitz, C K
AU  - Naspitz CK
FAU - Da Silva Patricio, F R
AU  - Da Silva Patricio FR
FAU - Neto, U F
AU  - Neto UF
FAU - De Morais, M B
AU  - De Morais MB
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Constipation/*etiology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Milk Hypersensitivity/blood/*complications
MH  - Radioallergosorbent Test
MH  - Skin Tests
EDAT- 2002/02/16 10:00
MHDA- 2002/03/13 10:01
CRDT- 2002/02/16 10:00
PHST- 2002/02/16 10:00 [pubmed]
PHST- 2002/03/13 10:01 [medline]
PHST- 2002/02/16 10:00 [entrez]
AID - 057 [pii]
AID - 10.1034/j.1399-3038.2001.0o057.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2001 Dec;12(6):339-42. doi: 
      10.1034/j.1399-3038.2001.0o057.x.