PMID- 11847164
OWN - NLM
STAT- MEDLINE
DCOM- 20020226
LR  - 20190503
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Print)
IS  - 1355-6037 (Linking)
VI  - 87
IP  - 3
DP  - 2002 Mar
TI  - Left ventricular diastolic function assessed using Doppler tissue imaging in 
      patients with hypertrophic cardiomyopathy: relation to symptoms and exercise 
      capacity.
PG  - 247-51
AB  - BACKGROUND: Conventional Doppler indices of left ventricular diastolic function 
      do not correlate with symptoms or exercise capacity in patients with hypertrophic 
      cardiomyopathy, because of their dependence on loading conditions. Diastolic 
      mitral annular velocity measured using Doppler tissue imaging has been reported 
      to be a preload independent index of left ventricular diastolic function. 
      OBJECTIVE: To determine the relation between diastolic annular velocities 
      combined with conventional Doppler indices and symptoms or exercise capacity in 
      hypertrophic cardiomyopathy. METHODS: 85 patients with hypertrophic 
      cardiomyopathy and 60 normal controls were studied. Diastolic mitral annular 
      velocities, transmitral left ventricular filling, and pulmonary venous velocities 
      were measured. RESULTS: Early diastolic velocities at lateral and septal annulus 
      were lower in patients with hypertrophic cardiomyopathy than in controls (lateral 
      Ea: 10 (3) v 18 (4) cm/s, p < 0.0001; septal Ea: 7 (2) v 12 (3) cm/s, p < 
      0.0001). Unlike conventional Doppler indices alone, transmitral early left 
      ventricular filling velocity (E) to lateral Ea ratio correlated inversely with 
      peak oxygen consumption (r = -0.42, p < 0.0001). Patients in New York Heart 
      Association (NYHA) class III had a higher transmitral E to lateral Ea ratio (12.0 
      (4.6)) than those in NYHA class II (7.6 (3.1), p < 0.005) or class I (6.6 (2.6), 
      p < 0.0001). CONCLUSIONS: Early diastolic mitral annular velocities are reduced 
      in patients with hypertrophic cardiomyopathy. Unlike conventional Doppler indices 
      alone, the transmitral E to lateral Ea ratio correlates with NYHA functional 
      class and exercise capacity.
FAU - Matsumura, Y
AU  - Matsumura Y
AD  - Department of Cardiological Sciences, St George's Hospital Medical School, London 
      SW17, UK.
FAU - Elliott, P M
AU  - Elliott PM
FAU - Virdee, M S
AU  - Virdee MS
FAU - Sorajja, P
AU  - Sorajja P
FAU - Doi, Y
AU  - Doi Y
FAU - McKenna, W J
AU  - McKenna WJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Flow Velocity
MH  - Cardiomyopathy, Hypertrophic/diagnostic imaging/*physiopathology
MH  - Child
MH  - Cohort Studies
MH  - Diastole/physiology
MH  - Echocardiography, Doppler/methods
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/physiology
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*physiopathology
MH  - Ventricular Function, Left/physiology
PMC - PMC1767026
EDAT- 2002/02/16 10:00
MHDA- 2002/02/28 10:01
PMCR- 2005/03/01
CRDT- 2002/02/16 10:00
PHST- 2002/02/16 10:00 [pubmed]
PHST- 2002/02/28 10:01 [medline]
PHST- 2002/02/16 10:00 [entrez]
PHST- 2005/03/01 00:00 [pmc-release]
AID - 0870247 [pii]
AID - 10.1136/heart.87.3.247 [doi]
PST - ppublish
SO  - Heart. 2002 Mar;87(3):247-51. doi: 10.1136/heart.87.3.247.