PMID- 11848533
OWN - NLM
STAT- MEDLINE
DCOM- 20020312
LR  - 20041117
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 21
IP  - 5
DP  - 2001 Sep-Oct
TI  - Plasmatic cytokine network in patients with laryngeal carcinoma after surgical 
      treatment.
PG  - 3621-5
AB  - Alterations in host immunity, inflammation, angiogenesis and metabolism are all 
      prominent clinical features in patients with laryngeal squamous cell carcinoma 
      (LSCC). Although the origin of the signals and mechanisms underlying these 
      responses are not well understood, their local and systematic nature suggest that 
      squamous cell carcinoma-produced cytokines with proinflammatory and 
      immunoregulatory activity may contribute to the pathogenesis of LSCC. In order to 
      gain a better insight into the roles and relationships of the cytokines, we 
      investigated serum IL-6, IL-10 and IL-12 concentrations in LSCC patients under 
      baseline conditions and after surgery. In comparison with controls, all the 
      patients had higher plasma IL-10 concentrations before surgical treatment (T0), 
      while plasma IL-6 and IL-12 concentrations were higher in 22 (84.6%) and 24 
      patients (92.3%). The differences in plasma IL-6, IL-10 and IL-12 concentrations 
      at T0 and T1 were statistically significant (p<0.001, p<0.0046 and p<0.011). Our 
      finding suggest that plasma cytokines are overexpressed in LSCC patients. There 
      was an independent increase in plasma IL-6 levels before and after surgical 
      treatment. Furthermore, the up- and down-regulation of plasma IL-10 and IL-12 
      suggest a regulatory relationship between them.
FAU - Pignataro, L
AU  - Pignataro L
AD  - Clinica Otorinolaringoiatrica, Ospedale Maggiore I.R.C.C.S. Milano, Italy. 
      lorenzo.pignataro@unimi.it
FAU - Corsi, M M
AU  - Corsi MM
FAU - Sambataro, G
AU  - Sambataro G
FAU - Porcaro, L
AU  - Porcaro L
FAU - Tredici, P
AU  - Tredici P
FAU - Broich, G
AU  - Broich G
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukins)
RN  - 130068-27-8 (Interleukin-10)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*blood/pathology/surgery
MH  - Female
MH  - Humans
MH  - Interleukin-10/blood
MH  - Interleukin-12/blood
MH  - Interleukin-6/blood
MH  - Interleukins/*blood
MH  - Laryngeal Neoplasms/*blood/pathology/surgery
MH  - Male
MH  - Middle Aged
EDAT- 2002/02/19 10:00
MHDA- 2002/03/13 10:01
CRDT- 2002/02/19 10:00
PHST- 2002/02/19 10:00 [pubmed]
PHST- 2002/03/13 10:01 [medline]
PHST- 2002/02/19 10:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2001 Sep-Oct;21(5):3621-5.