PMID- 11849650
OWN - NLM
STAT- MEDLINE
DCOM- 20020418
LR  - 20190718
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 160
IP  - 2
DP  - 2002 Feb
TI  - Clinicopathological significance of lipid peroxidation in carotid plaques.
PG  - 289-96
AB  - Several reports have suggested an association between lipid peroxidation and 
      human carotid atherosclerosis, but few reports have demonstrated a link between 
      lipid peroxidation and carotid plaques in humans. In this study, we investigated 
      the relationship between clinical features, histopathological characteristics and 
      lipid peroxidation in patients undergoing carotid endarterectomy (CEA). Forty-one 
      carotid plaques were obtained. A portion of the most severe lesions was subjected 
      to histopathologic examination, and the remainder of the plaques examined for 
      lipid peroxidation. Thiobarbituric acid-reactive substances (TBARS) values were 
      determined as a marker for lipid peroxidation. The lipid-rich core (LC) and 
      macrophage infiltration (Mphi) component as a percentage of total plaque area 
      were measured morphometrically. Based on the results, all plaques were classified 
      into four groups. Group I (GI): LC <10%; Group IIa (GIIa): LC 10-30%, Mphi <5%; 
      Group IIb (GIIb): LC 10-30%, Mphi < or = 5%, and Group III (GIII): LC < or =30%. 
      The plaque TBARS values of GIII were significantly higher than those of GI, GIIa, 
      and GIIb. The TBARS values of GIIb were one-and-a-half times higher than those of 
      GIIa. Our results show that lipid peroxidation in carotid plaques is 
      significantly associated with carotid atherosclerosis, especially plaque 
      instability. These findings provide direct evidence of an association between 
      lipid peroxidation and human atherosclerosis.
FAU - Nishi, Kyoko
AU  - Nishi K
AD  - Department of Neurological Surgery, School of Medicine, The University of 
      Tokushima, 3-18-15, Tokushima Kuramoto-cho 770-8503, Japan. 
      neuros@clin.med.tokushima-u.ac.jp
FAU - Uno, Masaaki
AU  - Uno M
FAU - Fukuzawa, Kenji
AU  - Fukuzawa K
FAU - Horiguchi, Hidehisa
AU  - Horiguchi H
FAU - Shinno, Kiyohito
AU  - Shinno K
FAU - Nagahiro, Shinji
AU  - Nagahiro S
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Lipids)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carotid Arteries/metabolism
MH  - Carotid Artery Diseases/*metabolism/pathology
MH  - Endarterectomy, Carotid
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Vitro Techniques
MH  - *Lipid Peroxidation
MH  - Lipids/analysis
MH  - Macrophages/pathology
MH  - Male
MH  - Middle Aged
MH  - Thiobarbituric Acid Reactive Substances/analysis
EDAT- 2002/02/19 10:00
MHDA- 2002/04/19 10:01
CRDT- 2002/02/19 10:00
PHST- 2002/02/19 10:00 [pubmed]
PHST- 2002/04/19 10:01 [medline]
PHST- 2002/02/19 10:00 [entrez]
AID - S0021-9150(01)00583-4 [pii]
AID - 10.1016/s0021-9150(01)00583-4 [doi]
PST - ppublish
SO  - Atherosclerosis. 2002 Feb;160(2):289-96. doi: 10.1016/s0021-9150(01)00583-4.