PMID- 11850023
OWN - NLM
STAT- MEDLINE
DCOM- 20020517
LR  - 20190901
IS  - 0047-6374 (Print)
IS  - 0047-6374 (Linking)
VI  - 123
IP  - 6
DP  - 2002 Mar 31
TI  - Age differentially influences estrogen receptor-alpha (ERalpha) and estrogen 
      receptor-beta (ERbeta) gene expression in specific regions of the rat brain.
PG  - 593-601
AB  - Estradiol's ability to influence neurochemical events that are critical to female 
      reproductive cyclicity and behavior decreases with age. We tested the hypothesis 
      that decreases in estrogen receptor-alpha (ERalpha) and/or ERbeta mRNA explain 
      the brain's declining responsiveness to estradiol. We assessed ERalpha and ERbeta 
      mRNA levels in intact and ovariectomized estradiol-treated rats. ERbeta mRNA was 
      detected in several brain regions and decreased by middle-age in the cerebral 
      cortex and supraoptic nucleus of estradiol-treated rats. ERbeta mRNA levels 
      exhibited a diurnal rhythm in the suprachiasmatic nucleus of young and 
      middle-aged rats and this rhythm was blunted in old rats. We examined ERalpha 
      mRNA in the periventricular preoptic, medial preoptic, ventromedial and arcuate 
      nuclei, and it was decreased only in the periventricular preoptic nucleus of the 
      old rats. In summary, the expression of ERalpha and ERbeta mRNAs is 
      differentially modulated in the aging brain and changes are region specific.
FAU - Wilson, Melinda E
AU  - Wilson ME
AD  - Department of Physiology, College of Medicine, University of Kentucky, 800 Rose 
      Street, Lexington, KY 40536, USA.
FAU - Rosewell, Katherine L
AU  - Rosewell KL
FAU - Kashon, Michael L
AU  - Kashon ML
FAU - Shughrue, Paul J
AU  - Shughrue PJ
FAU - Merchenthaler, Istvan
AU  - Merchenthaler I
FAU - Wise, Phyllis M
AU  - Wise PM
LA  - eng
GR  - AG02224/AG/NIA NIH HHS/United States
GR  - AG05818/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Estrogen)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Aging/*genetics/metabolism
MH  - Animals
MH  - Brain/*metabolism
MH  - Cerebral Cortex/metabolism
MH  - Estradiol/metabolism
MH  - Estrogen Receptor alpha
MH  - Estrogen Receptor beta
MH  - Female
MH  - *Gene Expression
MH  - Ovariectomy
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Estrogen/*genetics
MH  - Suprachiasmatic Nucleus/metabolism
MH  - Supraoptic Nucleus/metabolism
EDAT- 2002/02/19 10:00
MHDA- 2002/05/23 10:01
CRDT- 2002/02/19 10:00
PHST- 2002/02/19 10:00 [pubmed]
PHST- 2002/05/23 10:01 [medline]
PHST- 2002/02/19 10:00 [entrez]
AID - S0047637401004067 [pii]
AID - 10.1016/s0047-6374(01)00406-7 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2002 Mar 31;123(6):593-601. doi: 10.1016/s0047-6374(01)00406-7.