PMID- 11850043
OWN - NLM
STAT- MEDLINE
DCOM- 20020404
LR  - 20190901
IS  - 0165-0270 (Print)
IS  - 0165-0270 (Linking)
VI  - 114
IP  - 1
DP  - 2002 Feb 15
TI  - Temporal transformation of multiunit activity improves identification of single 
      motor units.
PG  - 87-98
AB  - This report describes a temporally based method for identifying repetitive firing 
      of motor units. This approach is ideally suited to spike trains with negative 
      serially correlated inter-spike intervals (ISIs). It can also be applied to spike 
      trains in which ISIs exhibit little serial correlation if their coefficient of 
      variation (COV) is sufficiently low. Using a novel application of the Hough 
      transform, this method (i.e. the modified Hough transform (MHT)) maps motor unit 
      action potential (MUAP) firing times into a feature space with ISI and offset 
      (defined as the latency from an arbitrary starting time to the first MUAP in the 
      train) as dimensions. Each MUAP firing time corresponds to a pattern in the 
      feature space that represents all possible MUAP trains with a firing at that 
      time. Trains with stable ISIs produce clusters in the feature space, whereas 
      randomly firing trains do not. The MHT provides a direct estimate of mean firing 
      rate and its variability for the entire data segment, even if several individual 
      MUAPs are obscured by firings from other motor units. Addition of this method to 
      a shape-based classification approach markedly improved rejection of false 
      positives using simulated data and identified spike trains in whole muscle 
      electromyographic recordings from rats. The relative independence of the MHT from 
      the need to correctly classify individual firings permits a global description of 
      stable repetitive firing behavior that is complementary to shape-based approaches 
      to MUAP classification.
FAU - Schalk, Gerwin
AU  - Schalk G
AD  - Wadsworth Center, New York State Department of Health, P.O. Box 509, Empire State 
      Plaza, Albany, NY 12201-0509, USA. schalk@wadsworth.org
FAU - Carp, Jonathan S
AU  - Carp JS
FAU - Wolpaw, Jonathan R
AU  - Wolpaw JR
LA  - eng
GR  - NS 22189/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Neurosci Methods
JT  - Journal of neuroscience methods
JID - 7905558
SB  - IM
MH  - Action Potentials/physiology
MH  - Animals
MH  - Electromyography/*methods
MH  - H-Reflex/physiology
MH  - Motor Neurons/*physiology
MH  - Muscle, Skeletal/innervation/*physiology
MH  - Rats
MH  - Signal Processing, Computer-Assisted
EDAT- 2002/02/19 10:00
MHDA- 2002/04/05 10:01
CRDT- 2002/02/19 10:00
PHST- 2002/02/19 10:00 [pubmed]
PHST- 2002/04/05 10:01 [medline]
PHST- 2002/02/19 10:00 [entrez]
AID - S0165027001005179 [pii]
AID - 10.1016/s0165-0270(01)00517-9 [doi]
PST - ppublish
SO  - J Neurosci Methods. 2002 Feb 15;114(1):87-98. doi: 10.1016/s0165-0270(01)00517-9.