PMID- 11850077
OWN - NLM
STAT- MEDLINE
DCOM- 20020320
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 132
IP  - 2
DP  - 2002 Jan 15
TI  - Interstitial deletion of 20q in a patient with Waldenstrom macroglobulinemia 
      following chemotherapy.
PG  - 145-8
AB  - A 76-year-old male with a history of renal insufficiency was found to have 
      anemia, an IgM kappa paraprotein on serum immunofixation studies, absence of 
      lytic bone lesions, and findings in the bone marrow consistent with Waldenstrom 
      macroglobulinemia (WM). Cytogenetic studies including fluorescence in situ 
      hybridization (FISH) on the post-treatment bone marrow revealed the karyotype 
      46,XY,del(20)(q13.1q13.3). Less than 70 cases of karyotypic abnormalities in 
      patients with WM have been reported, which have shown no abnormalities specific 
      to WM. Monosomy or trisomy of chromosome 20 has been reported in approximately 
      eight cases, but to our knowledge this is the first case report of an 
      interstitial deletion of 20q, confirmed by FISH using chromosome 20 subtelomeric 
      specific probes. Interstitial deletions of 20q are known to occur in polycythemia 
      vera and other hematological malignancies, especially those of myeloid origin.
FAU - Blann, Melissa M
AU  - Blann MM
AD  - Department of Pathology, Texas Tech Medical Center, Lubbock, TX, USA.
FAU - Velagaleti, Gopalrao V N
AU  - Velagaleti GV
FAU - Morgan, David L
AU  - Morgan DL
FAU - Martinez, Rodolfo E
AU  - Martinez RE
FAU - Conlin, Phillip A
AU  - Conlin PA
FAU - Tonk, Vijay S
AU  - Tonk VS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 20
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Waldenstrom Macroglobulinemia/*drug therapy/*genetics
EDAT- 2002/02/19 10:00
MHDA- 2002/03/21 10:01
CRDT- 2002/02/19 10:00
PHST- 2002/02/19 10:00 [pubmed]
PHST- 2002/03/21 10:01 [medline]
PHST- 2002/02/19 10:00 [entrez]
AID - S0165460801005386 [pii]
AID - 10.1016/s0165-4608(01)00538-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2002 Jan 15;132(2):145-8. doi: 
      10.1016/s0165-4608(01)00538-6.