PMID- 11850153
OWN - NLM
STAT- MEDLINE
DCOM- 20020402
LR  - 20161124
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 26
IP  - 3
DP  - 2002 Mar
TI  - The acute and chronic effects of MDMA ("ecstasy") on cortical 5-HT2A receptors in 
      rat and human brain.
PG  - 387-96
AB  - While the pre-synaptic effects of 3,4-methylenedioxymethamphetamine (MDMA) on 
      serotonin (5-HT) neurons have been studied extensively, little is known about its 
      effects on post-synaptic 5-HT(2) receptors. Therefore, cortical 5-HT(2A) receptor 
      densities and 5-HT concentration were studied in MDMA treated rats (10 mg/kg 
      s.c.). Furthermore, 5-HT(2A) post-synaptic receptor densities in the cerebral 
      cortex of recent as well as ex-MDMA users were studied using [123I]R91150 SPECT. 
      In rats we observed a decrease followed by a time-dependent recovery of cortical 
      5-HT(2A) receptor densities, which was strongly and positively associated with 
      the degree of 5-HT depletion. In recent MDMA users, post-synaptic 5-HT(2A) 
      receptor densities were significantly lower in all cortical areas studied, while 
      5-HT(2A) receptor densities were significantly higher in the occipital cortex of 
      ex-MDMA users. The combined results of this study suggest a compensatory 
      upregulation of post-synaptic 5-HT(2A) receptors in the occipital cortex of 
      ex-MDMA users due to low synaptic 5-HT levels.
FAU - Reneman, Liesbeth
AU  - Reneman L
AD  - Graduate School of Neurosciences, Department of Nuclear Medicine Academic Medical 
      Center, 1105 AZ Amsterdam, The Netherlands. l.reneman@amc.uva.nl
FAU - Endert, Erik
AU  - Endert E
FAU - de Bruin, Kora
AU  - de Bruin K
FAU - Lavalaye, Jules
AU  - Lavalaye J
FAU - Feenstra, Mathijs G
AU  - Feenstra MG
FAU - de Wolff, Freek A
AU  - de Wolff FA
FAU - Booij, Jan
AU  - Booij J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Piperidines)
RN  - 0 (R 91150)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Animals
MH  - Cerebral Cortex/diagnostic imaging/*drug effects/*metabolism
MH  - Down-Regulation/drug effects/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Piperidines/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Serotonin, 5-HT2A
MH  - Receptors, Serotonin/*metabolism
MH  - Serotonin/metabolism
MH  - Serotonin Agents/*administration & dosage
MH  - Tomography, Emission-Computed, Single-Photon/methods
MH  - Up-Regulation/drug effects/physiology
EDAT- 2002/02/19 10:00
MHDA- 2002/04/03 10:01
CRDT- 2002/02/19 10:00
PHST- 2002/02/19 10:00 [pubmed]
PHST- 2002/04/03 10:01 [medline]
PHST- 2002/02/19 10:00 [entrez]
AID - S0893133X01003669 [pii]
AID - 10.1016/S0893-133X(01)00366-9 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2002 Mar;26(3):387-96. doi: 
      10.1016/S0893-133X(01)00366-9.