PMID- 11852178
OWN - NLM
STAT- MEDLINE
DCOM- 20020425
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 320
IP  - 3
DP  - 2002 Mar 8
TI  - Differential electrophysiological effects of brain-derived neurotrophic factor on 
      dorsal horn neurons following chronic spinal cord hemisection injury in the rat.
PG  - 125-8
AB  - To assess the role of brain-derived neurotrophic factor (BDNF) in nociceptive 
      processing after chronic lateral spinal cord hemisection injury (SCI) at T13, we 
      studied the effects of BDNF on evoked activity of dorsal horn wide dynamic range 
      (WDR) neurons. Evoked responses of WDR cells (n=34 total) at L3-L5 were 
      characterized electrophysiologically after spinal administration of vehicle, or 
      BDNF (10 microg). In hemisected animals, application of BDNF to the surface of 
      the cord resulted in reductions in evoked activity in 24 of 32 cells (75%), and 
      enhancement of evoked activity in eight of 32 (25%) cells. Phosphate-buffered 
      saline-receiving animals demonstrated evoked response rates of between 75 and 93 
      Hz, while BDNF(-) cells had evoked rates from between 20 and 41 Hz, and BDNF(+) 
      activities were between 80 and 119 Hz, significant changes of 76 and 124%, 
      respectively. Effects were bilateral and differences in sidedness were not 
      observed. These results further implicate BDNF in nociceptive processing, but 
      suggest a complex role after chronic SCI.
FAU - Hains, Bryan C
AU  - Hains BC
AD  - Department of Anatomy and Neurosciences, and Marine Biomedical Institute, 
      University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 
      77555-1043, USA.
FAU - Willis, William D
AU  - Willis WD
FAU - Hulsebosch, Claire E
AU  - Hulsebosch CE
LA  - eng
GR  - NS11255/NS/NINDS NIH HHS/United States
GR  - NS39161/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Action Potentials/drug effects/*physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
MH  - Functional Laterality/drug effects/physiology
MH  - Hyperalgesia/metabolism/pathology/physiopathology
MH  - Male
MH  - Nociceptors/drug effects/*metabolism
MH  - Pain/*metabolism/pathology/physiopathology
MH  - Physical Stimulation
MH  - Posterior Horn Cells/drug effects/*metabolism/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord Injuries/*metabolism/pathology/physiopathology
MH  - Spinothalamic Tracts/drug effects/*metabolism/physiopathology
MH  - Synaptic Transmission/drug effects/physiology
EDAT- 2002/02/20 10:00
MHDA- 2002/04/26 10:01
CRDT- 2002/02/20 10:00
PHST- 2002/02/20 10:00 [pubmed]
PHST- 2002/04/26 10:01 [medline]
PHST- 2002/02/20 10:00 [entrez]
AID - S0304394002000265 [pii]
AID - 10.1016/s0304-3940(02)00026-5 [doi]
PST - ppublish
SO  - Neurosci Lett. 2002 Mar 8;320(3):125-8. doi: 10.1016/s0304-3940(02)00026-5.