PMID- 11852516
OWN - NLM
STAT- MEDLINE
DCOM- 20020904
LR  - 20061115
IS  - 0004-0614 (Print)
IS  - 0004-0614 (Linking)
VI  - 54
IP  - 10
DP  - 2001 Dec
TI  - [Primary neuroectodermal tumor (PNET) of the kidney: 26 cases. Current status of 
      its diagnosis and treatment].
PG  - 1081-93
AB  - OBJECTIVE: To report a case of primitive neuroectodermal tumor (PNET) of the 
      kidney and review the literature and the 25 cases previously reported as PNET. 
      METHODS: A 39-year-old man who consulted for nephric colic is described. 
      Ultrasound evaluation disclosed a mass arising from the left kidney. The 
      clinical, radiological and pathologic features, treatment and differential 
      diagnosis of small cell tumors are discussed, as well as the important role of 
      immunohistochemical techniques (positive staining with O13 or 12E7 antibodies) 
      and cytogenetic analysis [a characteristic chromosomal translocation t(11;22) 
      (q24;q12) or variant translocation, such as t(21;22) (q22;q12), may be detected 
      by fluorescence in situ hybridization (FISH) or polymerase chain reaction-reverse 
      transcriptase (PCR-RT)]. RESULTS: Survival of our patient was 20 months. Only 
      three of the 25 previously reported cases had a longer survival: 60, 48 and 24 
      months. Mean survival was 10 months. 95.24% of the cases were positive for NSE. 
      Immunostaining (CD99) was performed in 16 patients and was found to be positive 
      in all cases. Cytogenetic and molecular analyses were performed in 11 cases; 
      PCR-RT was negative in two, as well as in the case described herein. CONCLUSIONS: 
      PNET is a highly aggressive neoplasm that tends to recur locally and to 
      metastasize. Despite the poor response to standard therapy combining surgical 
      resection, postoperative irradiation and chemotherapy, the results might change 
      due to current research on genetic therapy based on creating antisense 
      oligonucleotides against the EWS-FLI 1 fusion gene.
FAU - Cuesta Alcala, J A
AU  - Cuesta Alcala JA
AD  - Servicio de Urologia y Anatomia Patologica, Hospital de Navarra, Pamplona, 
      Espana.
FAU - Solchaga Martinez, A
AU  - Solchaga Martinez A
FAU - Caballero Martinez, M C
AU  - Caballero Martinez MC
FAU - Gomez Dorronsoro, M
AU  - Gomez Dorronsoro M
FAU - Pascual Piedrola, I
AU  - Pascual Piedrola I
FAU - Ripa Saldias, L
AU  - Ripa Saldias L
FAU - Aldave Villanueva, J
AU  - Aldave Villanueva J
FAU - Arrondo Arrondo, J L
AU  - Arrondo Arrondo JL
FAU - Grasa Lanau, V
AU  - Grasa Lanau V
FAU - Ponz Gonzalez, M
AU  - Ponz Gonzalez M
FAU - Ipiens Aznar, A
AU  - Ipiens Aznar A
LA  - spa
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Tumor neuroectodermico primitivo renal (PNET): 26 casos. Estado actual de su 
      diagnostico y tratamiento.
PL  - Spain
TA  - Arch Esp Urol
JT  - Archivos espanoles de urologia
JID - 0064757
SB  - IM
MH  - Adult
MH  - Humans
MH  - Kidney Neoplasms/*diagnosis/*therapy
MH  - Male
MH  - Neuroectodermal Tumors, Primitive/*diagnosis/*therapy
RF  - 19
EDAT- 2002/02/21 10:00
MHDA- 2002/09/06 10:01
CRDT- 2002/02/21 10:00
PHST- 2002/02/21 10:00 [pubmed]
PHST- 2002/09/06 10:01 [medline]
PHST- 2002/02/21 10:00 [entrez]
PST - ppublish
SO  - Arch Esp Urol. 2001 Dec;54(10):1081-93.