PMID- 11852900
OWN - NLM
STAT- MEDLINE
DCOM- 20020815
LR  - 20211203
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 21
IP  - 4
DP  - 2002 Jan
TI  - Tribal and geographical variations of lupus in the Sultanate of Oman: a 
      hospital-based study.
PG  - 141-5
AB  - Tribal differences are demonstrated in the presentation of lupus in Omani Gulf 
      Arabs (OGA) and Omani Arabs of Persian descent (OAP), both groups resident in and 
      indigenous to the Sultanate of Oman. The OAP have a lower risk of joint 
      complications, skin rash, and dsDNA antibodies than OGA (beta coefficient and 95% 
      confidence interval [CI], -35.6, -16.4, and -2.31 and -38.05 to -33.06, -19.49 to 
      -13.3, and -4.1 to -0.6, respectively). The OGA have higher levels of IgG isotype 
      APL antibodies than OAP, both anticardiolipin (ACA) (t= 1.75, P= 1.04) and 
      anti-beta2glycoprotein I (infinitybeta2GPI) (t=3.64, P=0.004) antibodies, while 
      OAP have higher levels of ACAs, IgM isotype (t=2.86, P=0.0024), than OGA. 
      Antiphospholipid (APL) antibodies associate differently with clinical symptoms, 
      both within OAP and between OAP and OGA. Patients from Dakiliyah have a higher 
      risk of joint disease than those from Muscat (relative risk ratio 5.0, 95% CI 
      1.3-18.3). Differences in symptomatology suggest variations in genetic linkages 
      to human systemic lupus erythematosus.
FAU - Al Maini, M H
AU  - Al Maini MH
AD  - Department of Medicine and Immunology, College of Medicine, Sultan Qaboos 
      University, Muscat, Sultanate of Oman.
FAU - El-Ageb, El-Nour
AU  - El-Ageb el-N
FAU - Al-Shukaily, A K
AU  - Al-Shukaily AK
FAU - Al-Wahaibi, S
AU  - Al-Wahaibi S
FAU - Richens, E R
AU  - Richens ER
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Antibodies, Antiphospholipid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Antibodies, Antiphospholipid/genetics/*immunology
MH  - Cohort Studies
MH  - Developing Countries
MH  - Ethnicity/*genetics
MH  - Female
MH  - Hospitals
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*ethnology/genetics/*immunology
MH  - Male
MH  - Multivariate Analysis
MH  - Oman/epidemiology
MH  - Prevalence
MH  - Regression Analysis
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sex Distribution
EDAT- 2002/02/21 10:00
MHDA- 2002/08/16 10:01
CRDT- 2002/02/21 10:00
PHST- 2002/02/21 10:00 [pubmed]
PHST- 2002/08/16 10:01 [medline]
PHST- 2002/02/21 10:00 [entrez]
AID - 10.1007/s00296-001-0151-1 [doi]
PST - ppublish
SO  - Rheumatol Int. 2002 Jan;21(4):141-5. doi: 10.1007/s00296-001-0151-1.