PMID- 11852966
OWN - NLM
STAT- MEDLINE
DCOM- 20020430
LR  - 20191105
IS  - 0887-9303 (Print)
IS  - 0887-9303 (Linking)
VI  - 22
IP  - 4
DP  - 2000 Feb
TI  - New antithrombotics for the intensive care unit setting: GP IIb/IIIa inhibitors, 
      low-molecular-weight heparins, and direct thrombin inhibitors.
PG  - 61-74
AB  - Thromboembolic disease (TED) is a frequent problem encountered by clinicians in 
      the intensive care unit (ICU). Traditionally, unfractionated heparin (UFH) has 
      been used in the treatment and prophylaxis of TED. However, newer antithrombotic 
      agents have evolved as effective alternatives to UFH. Low-molecular-weight 
      heparins are effective for both the treatment and prophylaxis of TED. Lepirudin 
      is useful for patients with TED and a history of heparin-induced 
      thrombocytopenia. The platelet glycoprotein IIb/IIIa inhibitors are synergistic 
      with UFH for the treatment of acute coronary syndromes and percutaneous coronary 
      interventions (PCI). Several drugs are now available to clinicians for the 
      treatment and prophylaxis of TED.
FAU - DiDomenico, R J
AU  - DiDomenico RJ
AD  - Department of Pharmacy Practice, College of Pharmacy, University of Illinois at 
      Chicago, 60612, USA. rdidom1@uic.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Crit Care Nurs Q
JT  - Critical care nursing quarterly
JID - 8704517
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Platelet Glycoprotein GPIIb-IIIa Complex)
RN  - EC 3.4.21.5 (Thrombin)
MH  - Blood Coagulation/drug effects/physiology
MH  - *Fibrinolytic Agents/economics/pharmacology/therapeutic use
MH  - *Heparin, Low-Molecular-Weight/economics/pharmacology/therapeutic use
MH  - Humans
MH  - Intensive Care Units
MH  - Platelet Glycoprotein GPIIb-IIIa Complex/*antagonists & inhibitors
MH  - Thrombin/*antagonists & inhibitors
RF  - 72
EDAT- 2002/02/21 10:00
MHDA- 2002/05/01 10:01
CRDT- 2002/02/21 10:00
PHST- 2002/02/21 10:00 [pubmed]
PHST- 2002/05/01 10:01 [medline]
PHST- 2002/02/21 10:00 [entrez]
AID - 10.1097/00002727-200002000-00007 [doi]
PST - ppublish
SO  - Crit Care Nurs Q. 2000 Feb;22(4):61-74. doi: 10.1097/00002727-200002000-00007.