PMID- 11853612
OWN - NLM
STAT- MEDLINE
DCOM- 20051122
LR  - 20131121
IS  - 0412-4081 (Print)
IS  - 0412-4081 (Linking)
VI  - 36
IP  - 4
DP  - 2000 Jul
TI  - [An experimental research of taurine on H2O2-induced bovine lens epithelial cell 
      apoptosis].
PG  - 272-4, 17
AB  - OBJECTIVE: To study the inhibitory role of taurine on H(2)O(2)-induced bovine 
      lens epithelial cell apoptosis. METHODS: By terminal deoxyribonucleotide 
      transferase-mediated dUTP nick end labeling (TUNEL) detection and bovine lens 
      organ culture, we examined the affect of taurine on the number of 
      H(2)O(2)-induced bovine lens epithelial cells with apoptosis, the related 
      comparisons and statistic analyses were carried out. RESULTS: (1) Lens epithelial 
      cell apoptosis began before lens opaqueness (lens became opaque after 6 hours of 
      incubation, while the lens epithelial cell apoptosis was detected after 3 hours 
      of incubation); (2) Taurine could apparently inhibit H(2)O(2)-induced bovine lens 
      epithelial cell apoptosis. CONCLUSION: Taurine has an inhibitory role on 
      H(2)O(2)-induced bovine lens epithelial cell apoptosis and can delay and 
      ameliorate the occurrence and development of cataract.
FAU - Chen, F
AU  - Chen F
AD  - Beijing Institute of Ophthalmology, Beijing 100005, China.
FAU - Chen, C
AU  - Chen C
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yan Ke Za Zhi
JT  - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
JID - 16210540R
RN  - 1EQV5MLY3D (Taurine)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Cattle
MH  - Cells, Cultured
MH  - Epithelial Cells/drug effects/*pathology
MH  - Hydrogen Peroxide/adverse effects
MH  - Lens, Crystalline/*pathology
MH  - Taurine/*pharmacology
EDAT- 2002/02/21 10:00
MHDA- 2005/12/13 09:00
CRDT- 2002/02/21 10:00
PHST- 2002/02/21 10:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2002/02/21 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Yan Ke Za Zhi. 2000 Jul;36(4):272-4, 17.