PMID- 11856880
OWN - NLM
STAT- MEDLINE
DCOM- 20020416
LR  - 20171101
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 94
IP  - 3-4
DP  - 2001
TI  - The canine ERBB2 gene maps to a chromosome region frequently affected by 
      aberrations in tumors of the dog (Canis familiaris).
PG  - 194-5
AB  - The dog offers an increasingly important model for several human diseases, 
      including cancer. Accordingly, the results of canine gene mapping studies will be 
      of considerable significance. Herein, we have addressed the mapping of the canine 
      gene ERBB2 (alias HER2, NEU). ERBB2 is a protooncogene encoding a tyrosine kinase 
      receptor protein, the overexpression of which correlates with a more rapid 
      progression and a worse prognosis in breast cancer. In addition, it apparently 
      plays a role in the development of other tumors as well. By fluorescence in situ 
      hybridization (FISH), we have mapped the canine ERBB2 to 1q13.1. Cytogenetic 
      studies of canine tumors revealed that this region is very often affected by 
      clonal chromosome aberrations in tumors of the dog.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Murua Escobar, H
AU  - Murua Escobar H
AD  - Center for Human Genetics, University of Bremen, Germany.
FAU - Becker, K
AU  - Becker K
FAU - Bullerdiek, J
AU  - Bullerdiek J
FAU - Nolte, I
AU  - Nolte I
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Animals
MH  - *Chromosome Aberrations
MH  - Chromosomes/genetics
MH  - Dog Diseases/*genetics
MH  - Dogs/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Neoplasms/*genetics/*veterinary
MH  - *Physical Chromosome Mapping
MH  - Receptor, ErbB-2/*genetics
EDAT- 2002/02/22 10:00
MHDA- 2002/04/17 10:01
CRDT- 2002/02/22 10:00
PHST- 2002/02/22 10:00 [pubmed]
PHST- 2002/04/17 10:01 [medline]
PHST- 2002/02/22 10:00 [entrez]
AID - 48815 [pii]
AID - 10.1159/000048815 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 2001;94(3-4):194-5. doi: 10.1159/000048815.