PMID- 11857486
OWN - NLM
STAT- MEDLINE
DCOM- 20020610
LR  - 20111117
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 196
IP  - 3
DP  - 2002 Mar
TI  - HLA-G and its KIR ligands in cancer--another enigma yet to be solved?
PG  - 252-3
AB  - Alterations of antigen-presenting human leukocyte antigen (HLA) molecules often 
      occur in cancer and represent one of the mechanisms by which tumours evade host 
      immunosurveillance. One such molecule, HLA-G, was recently implicated in the same 
      context. HLA-G is thought to mediate the tolerance of the semi-allogeneic fetus 
      during pregnancy, by inhibiting maternal immune response through interaction with 
      different HLA-G-recognizing killer-cell inhibitory receptors (KIRs). A report in 
      this issue of the journal demonstrates for the first time the expression of HLA-G 
      and its KIR ligand, ILT-2 in human breast cancer. Apart from the up-regulation on 
      tumour cells, the authors describe HLA-G induction on the macrophages and T cells 
      infiltrating the breast cancer lesions. Moreover, a subset of infiltrating cells 
      also expressed HLA-G-recognizing KIR, ILT-2. This editorial discusses the 
      induction of HLA-G and related KIR molecules as another mechanism for tumours to 
      escape immune recognition.
CI  - Copyright 2002 John Wiley & Sons, Ltd.
FAU - Urosevic, Mirjana
AU  - Urosevic M
FAU - Trojan, Andreas
AU  - Trojan A
FAU - Dummer, Reinhard
AU  - Dummer R
LA  - eng
PT  - Comment
PT  - Editorial
PT  - Review
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
CON - J Pathol. 2002 Mar;196(3):266-74. PMID: 11857488
MH  - Breast Neoplasms/*immunology
MH  - Female
MH  - HLA Antigens/*immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Receptors, Immunologic/*immunology
MH  - Receptors, KIR
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - *Tumor Escape
RF  - 19
EDAT- 2002/02/22 10:00
MHDA- 2002/06/11 10:01
CRDT- 2002/02/22 10:00
PHST- 2002/02/22 10:00 [pubmed]
PHST- 2002/06/11 10:01 [medline]
PHST- 2002/02/22 10:00 [entrez]
AID - 10.1002/path.1057 [pii]
AID - 10.1002/path.1057 [doi]
PST - ppublish
SO  - J Pathol. 2002 Mar;196(3):252-3. doi: 10.1002/path.1057.