PMID- 11857612
OWN - NLM
STAT- MEDLINE
DCOM- 20020412
LR  - 20190906
IS  - 0197-3851 (Print)
IS  - 0197-3851 (Linking)
VI  - 22
IP  - 2
DP  - 2002 Feb
TI  - Prenatal diagnosis of a familial complex chromosomal rearrangement involving 
      chromosomes 5, 10, 16 and 18.
PG  - 102-4
AB  - We report one case of a familial complex chromosomal rearrangement (CCR) 
      involving four different chromosomes 5, 10, 16 and 18. The CCR was detected 
      prenatally at 20 weeks' gestation because of advanced maternal age and history of 
      recurrent miscarriages. Cytogenetic analysis of cultured amniotic fluid cells 
      with GTG banding showed a 46,XX,t(5;16;10;18)(q13;q22;q11.2;q21) karyotype. 
      Parental cytogenetic study revealed that the mother has the same CCR. RBG 
      banding, high resolution banding and fluorescence in situ hybridization (FISH) 
      were used to characterize further and confirm the conventional banding data. No 
      physical abnormalities were shown in the targeted fetal ultrasonography 
      examination. The parents decided to continue the pregnancy. The child is now 2 
      years old and has neither congenital anomalies nor evidence of delayed 
      psychomotor development. The fetal targeted ultrasound and FISH analysis helped 
      us reassure fetal status.
CI  - Copyright 2002 John Wiley & Sons, Ltd.
FAU - Lee, M H
AU  - Lee MH
AD  - Laboratory of Medical Genetics, Samsung Cheil Hospital, Seoul, Korea. 
      bihuang@genzyme.com
FAU - Park, S Y
AU  - Park SY
FAU - Kim, Y M
AU  - Kim YM
FAU - Kim, J M
AU  - Kim JM
FAU - Han, J Y
AU  - Han JY
FAU - Kim, M Y
AU  - Kim MY
FAU - Ryu, H M
AU  - Ryu HM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
SB  - IM
MH  - Abortion, Habitual/genetics
MH  - Adult
MH  - Amniotic Fluid/cytology
MH  - Cells, Cultured
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - *Chromosomes, Human, Pair 10
MH  - *Chromosomes, Human, Pair 16
MH  - *Chromosomes, Human, Pair 18
MH  - *Chromosomes, Human, Pair 5
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Maternal Age
MH  - Pregnancy
MH  - Pregnancy, High-Risk
MH  - *Prenatal Diagnosis
MH  - Translocation, Genetic
MH  - Ultrasonography, Prenatal
EDAT- 2002/02/22 10:00
MHDA- 2002/04/16 10:01
CRDT- 2002/02/22 10:00
PHST- 2002/02/22 10:00 [pubmed]
PHST- 2002/04/16 10:01 [medline]
PHST- 2002/02/22 10:00 [entrez]
AID - 10.1002/pd.224 [pii]
AID - 10.1002/pd.224 [doi]
PST - ppublish
SO  - Prenat Diagn. 2002 Feb;22(2):102-4. doi: 10.1002/pd.224.