PMID- 11860191
OWN - NLM
STAT- MEDLINE
DCOM- 20020820
LR  - 20191025
IS  - 0272-4340 (Print)
IS  - 0272-4340 (Linking)
VI  - 21
IP  - 5
DP  - 2001 Oct
TI  - Expression of TrkB receptors in developing visual cortex is not regulated by 
      light.
PG  - 545-52
AB  - 1. Neurotrophins are very good candidates which relate electrical activity to 
      molecular changes in activity-dependent phenomena. They exert their action 
      through binding to specific tyrosine-kinase receptors: Trk receptors. It is 
      important to consider Trk distribution in order to understand better the role of 
      neurotrophins in the Central Nervous System (CNS). We focused our attention on 
      brain-derived neurotrophic factor (BDNF) Trk receptors (TrkB) during development 
      of the rat visual cortex, since this neurotrophin has been shown to play an 
      important role in visual system development and plasticity. 2. We investigated 
      the full length form of TrkB receptors considering both its total amount and its 
      cellular distribution. To address this issue we used an antibody that recognizes 
      the full length form of TrkB and we used it both in Western blot and 
      immunohistochemistry. 3. We found that the expression of TrkB receptor increases 
      during development, but that there is no effect on visual experience, since 
      dark-reared animals show the same protein level and pattern of TrkB expression 
      compared to age-matched, normally reared controls.
FAU - Tropea, D
AU  - Tropea D
AD  - Scuola Internazionale Superiore di Studi Avanzati, Trieste, Italy.
FAU - Domenici, L
AU  - Domenici L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/radiation effects
MH  - Darkness
MH  - Gene Expression Regulation, Developmental/*physiology/radiation effects
MH  - In Vitro Techniques
MH  - Light
MH  - Mice
MH  - Rats
MH  - Receptor, trkB/*genetics/radiation effects
MH  - Visual Cortex/growth & development/*metabolism
EDAT- 2002/02/28 10:00
MHDA- 2002/08/21 10:01
CRDT- 2002/02/28 10:00
PHST- 2002/02/28 10:00 [pubmed]
PHST- 2002/08/21 10:01 [medline]
PHST- 2002/02/28 10:00 [entrez]
AID - 10.1023/a:1013875508373 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2001 Oct;21(5):545-52. doi: 10.1023/a:1013875508373.