PMID- 11860824
OWN - NLM
STAT- MEDLINE
DCOM- 20041102
LR  - 20201208
IS  - 0254-6450 (Print)
IS  - 0254-6450 (Linking)
VI  - 21
IP  - 6
DP  - 2000 Dec
TI  - [Study on the relations between HLA-DRB 1 alleles and Helicobacter pylori 
      infection].
PG  - 417-9
AB  - OBJECTIVE: In order to study the relation between human leukocyte antigen (HLA) 
      DRB1 alleles and Helicobacter pylori (Hp) infection. METHODS: Hp-IgG antibody 
      from 46 gastric cancer (GC), 75 esophageal cancer and 100 population-based 
      controls were identified by Hp-IgG quantitative enzyme immunoassay. Biotest 
      HLA-DRB enzyme linked probe hybridization assay kit (low resolution) was used to 
      identify DRB1 alleles. RESULTS: (1) Frequency of DRB1 * 08 was significantly 
      higher in Hp-IgG positive group than in Hp-IgG negative group (13.1% vs 4.4%, 
      chi(2) = 11.14, P < 0.001). Frequency of DRB1 * 12 was significantly lower in 
      Hp-IgG positive group than in Hp-IgG negatives (5.4% vs 11.3%, chi(2) = 4.49, P < 
      0.05). (2) Frequency of DRB1 * 02 in GC was significantly higher than that of 
      controls. Frequency of DRB1 * 07 in GC was significantly lower than that of 
      controls. However, neither the frequency of DRB1 * 02 between Hp-IgG positive and 
      Hp-IgG negative groups nor the frequency of DRB1 * 07 between Hp-IgG positive and 
      Hp-IgG negative groups showed significant differences in GC and controls. 
      CONCLUSIONS: (1) HLA-DRB1 * 08 might serve a genetic risk factor for Hp infection 
      while DRB1 * 12 might play a role of protecting effect against Hp infection. (2) 
      DRB1 * 02 might be a genetic risk factor for GC while DRB1 * 07 might play a role 
      of protecting effect against GC. However, the relations between DRB1 * 02, DRB1 * 
      07 and GC were not associated with Hp infection.
FAU - Gao, C
AU  - Gao C
AD  - Department of Epidemiology, Jiangsu Institute of Cancer Research, Nanjing 210009, 
      China.
FAU - Li, Z
AU  - Li Z
FAU - Ding, J
AU  - Ding J
FAU - Wang, J
AU  - Wang J
FAU - Hu, X
AU  - Hu X
FAU - Liu, T
AU  - Liu T
FAU - Xu, T
AU  - Xu T
FAU - Li, H
AU  - Li H
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Liu Xing Bing Xue Za Zhi
JT  - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JID - 8208604
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Antibodies, Bacterial/blood
MH  - Esophageal Neoplasms/microbiology
MH  - Female
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Helicobacter Infections/*genetics
MH  - Helicobacter pylori/*genetics/immunology/isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stomach Neoplasms/genetics/*microbiology
EDAT- 2002/02/28 10:00
MHDA- 2004/11/04 09:00
CRDT- 2002/02/28 10:00
PHST- 2002/02/28 10:00 [pubmed]
PHST- 2004/11/04 09:00 [medline]
PHST- 2002/02/28 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Liu Xing Bing Xue Za Zhi. 2000 Dec;21(6):417-9.