PMID- 11860911
OWN - NLM
STAT- MEDLINE
DCOM- 20041102
LR  - 20131121
IS  - 0253-9624 (Print)
IS  - 0253-9624 (Linking)
VI  - 34
IP  - 2
DP  - 2000 Mar
TI  - [Studies on micronuclei induced by colchicine and cyclophosphamide using 
      multicolor fluorescence in situ hybridization].
PG  - 101-3
AB  - OBJECTIVE: To study chromosomal composition of micronuclei (MN) induced by 
      colchicine (COL) and cyclophosphamide (CP) in mouse bone marrow erythrocytes. 
      METHODS: Multicolor fluorescence in situ hybridization (FISH) with centromeric 
      and telomeric DNA probes was applied to analyze chromosomal composition of 
      micronuclei induced by COL and CP in mouse bone marrow erythrocytes. RESULTS: 
      About 83.5% of COL-induced MN revealed both centromeric and telomeric signals. Of 
      the CP-induced MN, 74.5% showed telomeric signals only. CONCLUSION: Majority of 
      COL-induced MN contain whole chromosome and that of CP-induced MN mainly contain 
      acentric fragments. Multicolor FISH with centromeric and telomeric DNA probes was 
      a precise technique for analyzing chromosomal composition of MN.
FAU - Yang, M
AU  - Yang M
AD  - Molecular Toxicology Labortory, Third Military University, Chongqing 400038, 
      China.
FAU - Cao, J
AU  - Cao J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yu Fang Yi Xue Za Zhi
JT  - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
JID - 7904962
RN  - 0 (Mutagens)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - SML2Y3J35T (Colchicine)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/ultrastructure
MH  - Chromosomes/chemistry
MH  - Colchicine/*toxicity
MH  - Cyclophosphamide/*toxicity
MH  - Female
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Male
MH  - Mice
MH  - Micronuclei, Chromosome-Defective/chemistry/*genetics
MH  - Micronucleus Tests
MH  - Mutagens/toxicity
EDAT- 2002/02/28 10:00
MHDA- 2004/11/04 09:00
CRDT- 2002/02/28 10:00
PHST- 2002/02/28 10:00 [pubmed]
PHST- 2004/11/04 09:00 [medline]
PHST- 2002/02/28 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Yu Fang Yi Xue Za Zhi. 2000 Mar;34(2):101-3.