PMID- 11862345
OWN - NLM
STAT- MEDLINE
DCOM- 20020402
LR  - 20131121
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 159
IP  - 2
DP  - 2002 Jan
TI  - A study of the effect of a single neurotoxic dose of 
      3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") on the subsequent long-term 
      behaviour of rats in the plus maze and open field.
PG  - 167-75
AB  - RATIONALE: Decreased 5-HT function has been shown to induce behaviour consistent 
      with an "anxiolytic" effect. Administration of a single dose of 
      3,4-methylenedioxymethamphetamine (MDMA; "ecstasy" 12.5 mg/kg IP) to rats results 
      in prolonged damage to central serotonergic nerve terminals. Thus we wished to 
      assess whether an MDMA-induced lesion may have longer-term behavioural 
      consequences. OBJECTIVE: The study was designed to examine the behaviour of 
      MDMA-pretreated and control animals in the elevated plus-maze and open field at a 
      number of time-points, up to 80 days, after the administration of a single 
      neurotoxic dose of MDMA (12.5 mg/kg IP). RESULTS: MDMA-pretreated Dark Agouti 
      rats demonstrated a statistically significant reduction in anxiety-related 
      behaviour, compared to saline-pretreated control rats, in both the elevated 
      plus-maze and open field when the rats were tested on day 73 (open field) and day 
      80 (plus maze) after MDMA administration. CONCLUSIONS: The behavioural 
      consequences of a single neurotoxic dose of MDMA can be demonstrated over 2 
      months after administration of the compound, thereby indicating that long-term 
      adaptive changes occur within the brain following the neurodegeneration of 5-HT 
      neurones produced by this recreationally used drug.
FAU - Mechan, Annis O
AU  - Mechan AO
AD  - Department of Pharmacology, School of Pharmacy, De Montfort University, The 
      Gateway, Leicester LE1 9BH, UK.
FAU - Moran, Paula M
AU  - Moran PM
FAU - Elliott, MartinJ
AU  - Elliott M
FAU - Young, Andrew J
AU  - Young AJ
FAU - Joseph, Michael H
AU  - Joseph MH
FAU - Green, RichardA
AU  - Green R
LA  - eng
PT  - Journal Article
DEP - 20011003
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Neurotoxins)
RN  - 0 (Serotonin Agents)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Anxiety/*chemically induced/psychology
MH  - Behavior, Animal/*drug effects/physiology
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - Motor Activity/drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurotoxins/toxicity
MH  - Rats
MH  - Serotonin Agents/*toxicity
MH  - Time
EDAT- 2002/02/28 10:00
MHDA- 2002/04/03 10:01
CRDT- 2002/02/28 10:00
PHST- 2001/03/01 00:00 [received]
PHST- 2001/08/04 00:00 [accepted]
PHST- 2002/02/28 10:00 [pubmed]
PHST- 2002/04/03 10:01 [medline]
PHST- 2002/02/28 10:00 [entrez]
AID - 10.1007/s002130100900 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2002 Jan;159(2):167-75. doi: 10.1007/s002130100900. 
      Epub 2001 Oct 3.