PMID- 11863403
OWN - NLM
STAT- MEDLINE
DCOM- 20020514
LR  - 20061115
IS  - 0306-9877 (Print)
IS  - 0306-9877 (Linking)
VI  - 58
IP  - 1
DP  - 2002 Jan
TI  - New antidepressant drugs that do not cross the blood-brain barrier.
PG  - 83-4
AB  - Stimulation of neurogenesis in the adult brain (i.e. in the hippocampus) has 
      recently been proposed as a putative mechanism of antidepressant action of drugs. 
      This effect of antidepressants may not be achieved by their primary action on 
      proliferating cells, but may involve the drug-triggered mobilization of trophic 
      factors, such as brain-derived neurotrophic factor (BDNF), glia-derived protein 
      S100 beta, or insulin-like growth factor I (IFG-I). Whereas BDNF and S100 beta 
      are produced in the brain, IGF-I is primarily released from peripheral tissues. 
      Administered peripherally, IGF-I increases hippocampal neurogenesis in the adult 
      rat. Because synthesis and release of IGF-I appear to be stimulated by 
      serotonergic mechanisms, we propose that antidepressants that affect serotonergic 
      mechanisms might be rendered more effective by mobilizing IGF-I. Moreover, we 
      suggest that new antidepressant drugs could be designed that would not enter into 
      the brain but would stimulate peripheral mediators such as IGF-I.
CI  - Copyright 2002 Harcourt Publishers Ltd.
FAU - Manev, H
AU  - Manev H
AD  - Psychiatric Institute, Department of Psychiatry, University of Illinois at 
      Chicago, Chicago, 606912, USA. hmanev@psych.uic.edu
FAU - Manev, R
AU  - Manev R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacokinetics
MH  - Blood-Brain Barrier
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Rats
EDAT- 2002/02/28 10:00
MHDA- 2002/05/15 10:01
CRDT- 2002/02/28 10:00
PHST- 2002/02/28 10:00 [pubmed]
PHST- 2002/05/15 10:01 [medline]
PHST- 2002/02/28 10:00 [entrez]
AID - S0306987701914628 [pii]
AID - 10.1054/mehy.2001.1462 [doi]
PST - ppublish
SO  - Med Hypotheses. 2002 Jan;58(1):83-4. doi: 10.1054/mehy.2001.1462.