PMID- 11866839
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1469-0691 (Electronic)
IS  - 1198-743X (Linking)
VI  - 2
IP  - 3
DP  - 1996 Feb
TI  - Novel human herpesviruses (human herpesviruses 6, 7 and 8).
PG  - 159-167
AB  - The number of members in the family Herpesviridae has increased in the last 10 
      years due to the description of three novel human herpesviruses: human 
      herpesvirus 6 (HHV-6) in 1986, human herpesvirus 7 (HHV-7) in 1990, and human 
      herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus 
      (KSHV), in 1994. HHV-6 and HHV-7 were first isolated from blood lymphocyte 
      cultures, while HHV-8 was identified following a specific molecular biology 
      approach in the search for the etiologic agent of Kaposi's sarcoma. The three 
      viruses are lymphotropic, T-cells being the targets of HHV-6 and HHV-7, and 
      B-cells being probably those of HHV-8. The ability to be propagated in cell 
      cultures in vitro differs according to the virus concerned: this can be done 
      readily with HHV-6, with more difficulties in the case of HHV-7, and has not yet 
      been achieved in the case of HHV-8. Human infection with HHV-6 and HHV-7 is 
      ubiquitous, widespread and acquired early in life. HHV-8 epidemiology is still 
      unclear, and there are two hypotheses: a restricted dissemination in the general 
      population like herpes simplex virus type 2, or a widespread infection like all 
      other human herpesviruses. The polymerase chain reaction is the common method for 
      the detection of infection using specific primers and probes for HHV-6, HHV-7 and 
      HHV-8 respectively. Serologic assays are only available for HHV-6 and HHV-7, with 
      limitations being due, in particular, to possible cross-reactions with 
      cytomegalovirus. HHV-6 is the causative agent of exanthem subitum (sixth 
      disease). Its role as an opportunistic agent and immune dysfunction inducer is 
      debated and currently under investigation. The pathogenic role of HHV-7 seems to 
      be modest, with one case of exanthem subitum reported so far. HHV-8 is strongly 
      associated with three diseases: Kaposi's sarcoma, Castleman's disease and 
      body-cavity-based lymphomas. The therapy against these novel viruses has to be 
      considered in the future.
FAU - Agut, Henri
AU  - Agut H
AD  - Virology Laboratory, CNRS EP57, CERVI, Pitie-Salpetriere Hospital, and.
FAU - Dupin, Nicolas
AU  - Dupin N
FAU - Aubin, Jean-Thierry
AU  - Aubin JT
FAU - Calvez, Vincent
AU  - Calvez V
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Microbiol Infect
JT  - Clinical microbiology and infection : the official publication of the European 
      Society of Clinical Microbiology and Infectious Diseases
JID - 9516420
EDAT- 1996/02/01 00:00
MHDA- 2002/02/28 10:00
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 2002/02/28 10:00 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - S1198-743X(14)65138-7 [pii]
AID - 10.1016/s1198-743x(14)65138-7 [doi]
PST - ppublish
SO  - Clin Microbiol Infect. 1996 Feb;2(3):159-167. doi: 10.1016/s1198-743x(14)65138-7.