PMID- 11866973
OWN - NLM
STAT- MEDLINE
DCOM- 20050315
LR  - 20160818
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 30
IP  - 3
DP  - 2001 Jun
TI  - [Clinical significance of c-myc oncogene amplification in primary hepatocellular 
      carcinoma by interphase fluorescence in situ hybridization].
PG  - 180-2
AB  - OBJECTIVE: To investigate the relationships between c-myc oncogene amplification 
      in primary hepatocellular carcinoma (HCC) and its clinical prognosis. METHODS: To 
      detect c-myc oncogene amplification in 100 cases with primary HCC and in 6 cases 
      with satellite nodes by interphase fluorescence in situ hybridization (FISH). 
      RESULTS: c-myc amplification was detected in 92 of 100 (92%) cases with HCC, 37 
      of which (37%) showed high copy amplification (HC), 55 (55%) low copy 
      amplification (LC) and 8 (8%) single copy or no amplification (SC). There wasn't 
      statistically different significance between the frequency of c-myc amplification 
      and clinical stage and tumor size, and pathological types (P > 0.05), however, in 
      the 90 follow-up resected cases, the one-year rates of recurrence in HC, LC and 
      SC were 70.6% (24/34), 39.6% (19/48) and 12.5% (1/8) respectively (P < 0.05) but 
      the recurrence rates after more than one year were 14.70% (5/34), 14.6% (7/48) 
      and 0 (0/8) respectively (P > 0.05). Meanwhile, two-year survival rate of 
      patients with HC was significantly lower in comparison with those with LC and SC 
      (P = 0.001). CONCLUSIONS: There is a high frequency of c-myc oncogene 
      amplification in primary HCC and the fact that the patients with HC showed poorer 
      prognosis indicates that the level of c-myc oncogene amplification may be a 
      sensitive index in the prognosis of HCC.
FAU - Fang, Y
AU  - Fang Y
AD  - Department of Etiology, Cancer Center, Sun Yat-sen University of Medical 
      Sciences, Guangzhou 510060, China.
FAU - Huang, B
AU  - Huang B
FAU - Liang, Q
AU  - Liang Q
FAU - Li, H
AU  - Li H
FAU - Huang, C
AU  - Huang C
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Hepatocellular/*genetics/pathology
MH  - Female
MH  - *Gene Amplification
MH  - Genes, myc/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Liver Neoplasms/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Prognosis
EDAT- 2002/02/28 10:00
MHDA- 2005/03/16 09:00
CRDT- 2002/02/28 10:00
PHST- 2002/02/28 10:00 [pubmed]
PHST- 2005/03/16 09:00 [medline]
PHST- 2002/02/28 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2001 Jun;30(3):180-2.