PMID- 11867001
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1470-1537 (Electronic)
IS  - 0969-7667 (Linking)
VI  - 7
IP  - 2
DP  - 2000 May
TI  - Chronic Fatigue Syndrome and Herpesviruses: the Fading Evidence.
PG  - 46-50
AB  - Herpesviruses, in particular Epstein-Barr virus (EBV), cytomegalovirus (CMV) and 
      human herpesvirus 6 (HHV-6), have, for the past two decades, come under 
      considerable scrutiny as aetiological agents of chronic fatigue syndrome (CFS). 
      However, virological findings of herpesviruses in CFS have not been consistent 
      between different studies, and the unusual patterns of serological responses to 
      EBV, CMV and HHV-6 have not been specific for CFS, being observed also in 
      asymptomatic individuals. In addition, patients with symptomatology suggestive of 
      CFS do not appear to have an increased frequency of these herpesviruses, as 
      detected by culture or polymerase chain reaction, compared with controls, which 
      argues against an ongoing active herpetic infection. Studies have also shown that 
      the presumable elevation of antibody titres to EBV, CMV or HHV-6 in CFS are not 
      observed only with these viruses, but also with other organisms such as herpes 
      simplex virus and measles.
FAU - Soto, Norberto E
AU  - Soto NE
AD  - National Institute of Allergy and Infectious Disease, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Straus, Stephen E
AU  - Straus SE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Herpes
JT  - Herpes : the journal of the IHMF
JID - 9801722
EDAT- 2002/02/28 10:00
MHDA- 2002/02/28 10:00
CRDT- 2002/02/28 10:00
PHST- 1999/11/17 00:00 [received]
PHST- 2000/01/28 00:00 [accepted]
PHST- 2002/02/28 10:00 [pubmed]
PHST- 2002/02/28 10:00 [medline]
PHST- 2002/02/28 10:00 [entrez]
PST - ppublish
SO  - Herpes. 2000 May;7(2):46-50.