PMID- 11867033
OWN - NLM
STAT- MEDLINE
DCOM- 20020402
LR  - 20191210
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 89
IP  - 5
DP  - 2002 Mar 1
TI  - Gender differences in acute myocardial infarction in the era of reperfusion (the 
      MITRA registry).
PG  - 511-7
AB  - There is conflicting information about gender differences in presentation, 
      treatment, and outcome after acute ST elevation myocardial infarction (STEMI) in 
      the era of thrombolytic therapy and primary percutaneous coronary intervention. 
      From June 1994 to January 1997, we enrolled 6,067 consecutive patients with STEMI 
      admitted to 54 hospitals in southwest Germany in the Maximal Individual TheRapy 
      of Acute myocardial infarction (MITRA), a community-based registry. Women were 9 
      years older than men, more often had hypertension, diabetes mellitus, and 
      congestive heart failure, and had a history of previous myocardial infarction 
      less often. Women had a longer prehospital delay (45 minutes), had anterior wall 
      infarction more often (odds ratio [OR] 1.21; 95% confidence interval [CI] 1.08 to 
      1.36), and received reperfusion therapy less often (OR 0.83; 95% CI 0.74 to 
      0.94). The percentage of patients who were eligible for thrombolysis and received 
      no reperfusion was higher in women (OR 1.7; 95% CI 1.56 to 1.89). Women had 
      recurrent angina (OR 1.45; 95% CI 1.23 to 1.71) and congestive heart failure (OR 
      1.26; 95% CI 1.01 to 1.56) more often. There was a trend toward a higher hospital 
      mortality in women (age-adjusted OR 1.16, 95% CI 0.99 to 1.35; multivariate OR 
      1.21, 95% CI 0.96 to 1.51), but there was no gender difference in long-term 
      mortality after multivariate analysis (age-adjusted OR 0.95, 95% CI 0.78 to 1.15; 
      multivariate OR 0.93, 95% CI 0.72 to 1.19). Thus, women with STEMI receive 
      reperfusion therapy less often than men. They experience recurrent angina and 
      congestive heart failure more often during their hospital stay. The age-adjusted 
      long-term mortality is not different between men and women, but there is a trend 
      for a higher short-term mortality in women.
FAU - Heer, Tobias
AU  - Heer T
AD  - Herzzentrum Ludwigshafen, Kardiologie, Ludwigshafen, Germany. 
      tobias.heer@planet.interkom.de
FAU - Schiele, Rudolf
AU  - Schiele R
FAU - Schneider, Steffen
AU  - Schneider S
FAU - Gitt, Anselm K
AU  - Gitt AK
FAU - Wienbergen, Harm
AU  - Wienbergen H
FAU - Gottwik, Martin
AU  - Gottwik M
FAU - Gieseler, Ulf
AU  - Gieseler U
FAU - Voigtlander, Thomas
AU  - Voigtlander T
FAU - Hauptmann, Karl E
AU  - Hauptmann KE
FAU - Wagner, Stefan
AU  - Wagner S
FAU - Senges, Jochen
AU  - Senges J
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Aged
MH  - Angina Pectoris/drug therapy/mortality
MH  - Emergency Medical Services/statistics & numerical data
MH  - Female
MH  - Germany
MH  - Heart Failure/drug therapy/mortality
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/drug therapy/*mortality
MH  - Prospective Studies
MH  - Registries
MH  - Sex Factors
MH  - Survival Analysis
MH  - Thrombolytic Therapy/statistics & numerical data
EDAT- 2002/02/28 10:00
MHDA- 2002/04/03 10:01
CRDT- 2002/02/28 10:00
PHST- 2002/02/28 10:00 [pubmed]
PHST- 2002/04/03 10:01 [medline]
PHST- 2002/02/28 10:00 [entrez]
AID - S0002914901022895 [pii]
AID - 10.1016/s0002-9149(01)02289-5 [doi]
PST - ppublish
SO  - Am J Cardiol. 2002 Mar 1;89(5):511-7. doi: 10.1016/s0002-9149(01)02289-5.