PMID- 11868921
OWN - NLM
STAT- MEDLINE
DCOM- 20020325
LR  - 20111117
IS  - 1081-1206 (Print)
IS  - 1081-1206 (Linking)
VI  - 88
IP  - 2
DP  - 2002 Feb
TI  - Positive association between HLA-DRB1*07 and specific IgE responses to purified 
      major allergens of D. pteronyssinus (Der p 1 and Der p 2).
PG  - 170-4
AB  - BACKGROUND AND OBJECTIVE: Human leukocyte antigen (HLA) class II gene products 
      are involved in the antigen presentation of exogenous antigens. The aim of this 
      study was to evaluate whether specific immunoglobulin (Ig)E responses to purified 
      major allergens of Dermatophagoides pteronyssinus (Der p 1 and Der p 2) were 
      associated with genotypes of HLA-DRB1 alleles. SUBJECTS AND METHODS: Peripheral 
      venous blood samples were collected from two groups of unrelated Korean 
      adolescents: 168 subjects with positive skin response (wheal > or = 3 mm) to 
      crude D. pteronyssinus allergens and 94 age-matched controls with negative skin 
      response and low serum-specific IgE to crude D. pteronyssinus allergens. The 
      former group was found to contain 104 with high serum-specific IgE to crude D. 
      pteronyssinus allergens, 100 with high serum-specific IgE to Der p 1, and 122 
      with high serum-specific IgE to Der p 2. Genotypes of the HLA-DRB1 alleles were 
      determined using polymerase chain reaction-sequence specific oligonucleotide 
      probes. RESULTS: HLA-DRB1*07 was significantly higher in subjects with a high 
      serum-specific IgE response to crude D. pteronyssinus allergens than the controls 
      (16.3% vs 3.2%, odds ratio [OR] = 5.93, corrected P [Pc] = 0.02). The excess of 
      DRB1*07 was more marked in those with high serum-specific IgE responses to Der p 
      1 or Der p 2 than the controls (20.0% vs 3.2%, OR = 7.58, Pc = 0.004; 18.9% vs 
      3.2%, OR = 7.05, Pc = 0.006). Among subjects with high serum IgE to Der p 1, 
      DRB1*13 significantly increased than the controls (32.0% vs 13.8%, OR = 2.93, Pc 
      = 0.03). CONCLUSIONS: We clearly observed the association between HLA-DRB1 
      alleles and specific IgE responsiveness to D. pteronyssinus major allergens. The 
      molecular mechanism of HLA-DRB1*07 and DRB1*13 involvement in D. 
      pteronyssinus-specific IgE responsiveness awaits further investigation.
FAU - Kim, Yoon-Keun
AU  - Kim YK
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      and Institute of Allergy and Clinical Immunology, Seoul National University 
      Medical Research Center, Korea.
FAU - Oh, Sun-Young
AU  - Oh SY
FAU - Oh, Heung-Bum
AU  - Oh HB
FAU - Lee, Byung-Jae
AU  - Lee BJ
FAU - Son, Jee-Woong
AU  - Son JW
FAU - Cho, Sang-Heon
AU  - Cho SH
FAU - Kim, You-Young
AU  - Kim YY
FAU - Min, Kyung-Up
AU  - Min KU
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Glycoproteins)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Antigens, Dermatophagoides
MH  - Female
MH  - Gene Frequency
MH  - Glycoproteins/adverse effects/*immunology
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Skin Tests
EDAT- 2002/03/01 10:00
MHDA- 2002/03/26 10:01
CRDT- 2002/03/01 10:00
PHST- 2002/03/01 10:00 [pubmed]
PHST- 2002/03/26 10:01 [medline]
PHST- 2002/03/01 10:00 [entrez]
AID - S1081-1206(10)61992-8 [pii]
AID - 10.1016/S1081-1206(10)61992-8 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2002 Feb;88(2):170-4. doi: 
      10.1016/S1081-1206(10)61992-8.