PMID- 11869363
OWN - NLM
STAT- MEDLINE
DCOM- 20020712
LR  - 20180822
IS  - 0818-9641 (Print)
IS  - 0818-9641 (Linking)
VI  - 80
IP  - 1
DP  - 2002 Feb
TI  - Recruitment of lymphocytes to the human liver.
PG  - 52-64
AB  - This review discusses the function and localisation of lymphocytes resident 
      within the human liver, under both physiological and pathological conditions. 
      Through description of the mechanisms that mediate lymphocyte recruitment into 
      tissues, this article explains how hepatic endothelial and epithelial cells 
      regulate the recruitment of specific lymphocyte subpopulations. We illustrate 
      that the expression of adhesion molecules and chemokines is crucial to the 
      control of lymphocyte adhesion. Thus, in the normal liver, adhesion molecules 
      such as vascular adhesion protein-1 (VAP-1), intercellular adhesion molecule-1 
      (ICAM-1) and intercellular adhesion molecule-2 (ICAM-2), and chemokines such as 
      regulated on activation, normal T cell expressed and secreted (RANTES), monocyte 
      chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha 
      (MIP-1alpha), interferon gamma inducible protein-10 (IP-10), MIG and interferon 
      inducible T-cell alpha chemoattractant (ITAC) are involved in lymphocyte binding 
      to different endothelial compartments. However, in response to inflammation or 
      injury, additional expression of adhesion molecules such as VCAM-1, p-selectin 
      and e-selectin, as well as higher levels of chemokines, permits the attraction 
      and retention of specific effector populations of lymphocytes. We also discuss 
      the expression and function of a newly defined adhesion protein, (VAP-1), and 
      suggest that the unique functions of this protein may provide therapeutic 
      potential for the treatment of liver disease.
FAU - Lalor, Patricia F
AU  - Lalor PF
AD  - Liver Research Laboratories, Universityof Birmingham MRC Centre for Immune 
      Regulation, Institute of Clinical Research,Queen Elizabeth Hospital, Edgbaston, 
      Birmingham, United Kingdom. P.F.LALOR@bham.ac.uk
FAU - Shields, Philip
AU  - Shields P
FAU - Grant, AllisterJ
AU  - Grant A
FAU - Adams, David H
AU  - Adams DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
SB  - IM
MH  - Animals
MH  - Cell Adhesion/immunology
MH  - Chemotaxis, Leukocyte/*immunology
MH  - Endothelium, Vascular/cytology/immunology
MH  - Humans
MH  - Liver/blood supply/*immunology
MH  - Lymphocytes/*immunology
RF  - 113
EDAT- 2002/03/01 10:00
MHDA- 2002/07/13 10:01
CRDT- 2002/03/01 10:00
PHST- 2002/03/01 10:00 [pubmed]
PHST- 2002/07/13 10:01 [medline]
PHST- 2002/03/01 10:00 [entrez]
AID - 1062 [pii]
AID - 10.1046/j.1440-1711.2002.01062.x [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2002 Feb;80(1):52-64. doi: 10.1046/j.1440-1711.2002.01062.x.