PMID- 11870910
OWN - NLM
STAT- MEDLINE
DCOM- 20020620
LR  - 20191105
IS  - 0952-3480 (Print)
IS  - 0952-3480 (Linking)
VI  - 15
IP  - 2
DP  - 2002 Apr
TI  - Reproducibility of quantitative dynamic MRI of normal human tissues.
PG  - 143-53
AB  - The aim of the study was to establish the normal range and to evaluate the 
      reproducibility of dynamic contrast enhanced MRI (DCE-MRI) parameter estimates in 
      normal human pelvic tissues. Nineteen patients with prostate cancer, undergoing 
      androgen deprivation treatment, had paired DCE-MRI examinations of the pelvis 
      using spoiled gradient-echo sequences. Quantitative enhancement parameters were 
      calculated for each examination: transfer constant (K(trans)), leakage space 
      (v(e)) and maximum contrast medium accumulation (MCMA) of pelvic muscles, bone 
      marrow and fat. Descriptive and reproducibility statistics were calculated: 
      within-patient standard deviation (wSD), repeatability and within-patient 
      coefficient of variation (wCV). The femoral head and ischiorectal fat showed 
      large numbers of non-enhancing pixels (81 and 88%, respectively). The ischial 
      bone marrow had the highest values of kinetic parameter estimates (K(trans) 0.554 
      min(-1), v(e) 18.5% and MCMA 0.164 mmol/kg). Muscle parameters values were lower 
      (K(trans) 0.126-0.137 min(-1), v(e) 10.6-11.5% and MCMA 0.077-0.086 mmol/kg). The 
      mean difference between paired examinations was not significantly different from 
      zero for any parameter. v(e) and MCMA had the lowest wCV (between 19 and 29%). 
      For individuals, a log(10) K(trans) change of approximately 0.90 in muscles and 
      0.52 in the ischium would be statistically significant. The corresponding 
      absolute changes for v(e) are 6.7% in muscle and 13.6% in the ischium. For a 
      group of 19 patients, small changes are statistically significant (muscle log(10) 
      K(trans) 0.208 and v(e) 1.5% and ischium log(10) K(trans) 0.123 and v(e) 3.1%). 
      Fat and the femoral head are unreliable tissues from which to obtain kinetic 
      parameter estimates due to poor enhancement. v(e) and MCMA have smaller 
      coefficient of variation than K(trans) in muscles and ischium. Reproducibility 
      studies of normal and pathological tissues should be incorporated into clinical 
      research protocols that measure treatment effects by DCE-MRI techniques.
CI  - Copyright 2002 John Wiley & Sons, Ltd.
FAU - Padhani, Anwar R
AU  - Padhani AR
AD  - CRC Clinical Magnetic Resonance Research Group, Institute of Cancer Research and 
      The Royal Marsden NHS Trust, Downs Road, Sutton, Surrey SM2 5PT, UK. 
      anwar@padhani.fsnet.co.uk
FAU - Hayes, Carmel
AU  - Hayes C
FAU - Landau, Sabine
AU  - Landau S
FAU - Leach, Martin O
AU  - Leach MO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - NMR Biomed
JT  - NMR in biomedicine
JID - 8915233
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adipose Tissue/*anatomy & histology
MH  - Bone Marrow/*anatomy & histology
MH  - Contrast Media
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Muscle, Skeletal/*anatomy & histology
MH  - Pelvis/*anatomy & histology
MH  - Prostatic Neoplasms/*pathology
MH  - Reproducibility of Results
EDAT- 2002/03/01 10:00
MHDA- 2002/06/21 10:01
CRDT- 2002/03/01 10:00
PHST- 2002/03/01 10:00 [pubmed]
PHST- 2002/06/21 10:01 [medline]
PHST- 2002/03/01 10:00 [entrez]
AID - 10.1002/nbm.732 [pii]
AID - 10.1002/nbm.732 [doi]
PST - ppublish
SO  - NMR Biomed. 2002 Apr;15(2):143-53. doi: 10.1002/nbm.732.