PMID- 11872258
OWN - NLM
STAT- MEDLINE
DCOM- 20020523
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 321
IP  - 1-2
DP  - 2002 Mar 15
TI  - Quetiapine attenuates the immobilization stress-induced decrease of brain-derived 
      neurotrophic factor expression in rat hippocampus.
PG  - 65-8
AB  - Quetiapine is a new atypical antipsychotic drug widely used in the treatment of 
      schizophrenia and other psychotic disorders. This study examined the influence of 
      quetiapine on the decrease of brain-derived neurotrophic factor (BDNF) 
      expression, induced by chronic immobilization stress, in the hippocampus of the 
      rat. Pretreatment with 10 mg/kg of quetiapine markedly attenuated the 
      stress-induced decrease in levels of BDNF protein, as determined by Western blot 
      analyses, and the reduction of BDNF immunoreactivity, in hippocampal pyramidal 
      and dentate granular neurons. These results suggest that the chronic 
      administration of quetiapine could be neuroprotective to hippocampal neurons in 
      schizophrenia and this effect may be related to its antipsychotic effect in 
      patients with schizophrenia.
FAU - Xu, Haiyun
AU  - Xu H
AD  - Neuropsychiatric Research Unit, Department of Psychiatry, University of 
      Saskatchewan, 103 Wiggins Road, Saskatoon, SK S7N 5E4, Canada.
FAU - Qing, Hong
AU  - Qing H
FAU - Lu, Wenfu
AU  - Lu W
FAU - Keegan, David
AU  - Keegan D
FAU - Richardson, J Steven
AU  - Richardson JS
FAU - Chlan-Fourney, Jennifer
AU  - Chlan-Fourney J
FAU - Li, Xin Min
AU  - Li XM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dibenzothiazepines)
RN  - 2S3PL1B6UJ (Quetiapine Fumarate)
SB  - IM
MH  - Animals
MH  - Antipsychotic Agents/*pharmacology
MH  - Apoptosis/drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Dibenzothiazepines/*pharmacology
MH  - Hippocampus/*drug effects/metabolism/physiopathology
MH  - Immunohistochemistry
MH  - Male
MH  - Nerve Degeneration/drug therapy/pathology/physiopathology
MH  - Neurons/*drug effects/metabolism
MH  - Quetiapine Fumarate
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Schizophrenia/*drug therapy/pathology/physiopathology
MH  - Stress, Physiological/*drug therapy/metabolism/physiopathology
EDAT- 2002/03/02 10:00
MHDA- 2002/05/25 10:01
CRDT- 2002/03/02 10:00
PHST- 2002/03/02 10:00 [pubmed]
PHST- 2002/05/25 10:01 [medline]
PHST- 2002/03/02 10:00 [entrez]
AID - S0304394002000344 [pii]
AID - 10.1016/s0304-3940(02)00034-4 [doi]
PST - ppublish
SO  - Neurosci Lett. 2002 Mar 15;321(1-2):65-8. doi: 10.1016/s0304-3940(02)00034-4.