PMID- 11872844
OWN - NLM
STAT- MEDLINE
DCOM- 20020327
LR  - 20141120
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 295
IP  - 5560
DP  - 2002 Mar 1
TI  - Postsynaptic Induction of BDNF-Mediated Long-Term Potentiation.
PG  - 1729-34
AB  - Brain-derived neurotrophic factor (BDNF) and other neurotrophins are critically 
      involved in long-term potentiation (LTP). Previous reports point to a presynaptic 
      site of neurotrophin action. By imaging dentate granule cells in mouse 
      hippocampal slices, we identified BDNF-evoked Ca2+ transients in dendrites and 
      spines, but not at presynaptic sites. Pairing a weak burst of synaptic 
      stimulation with a brief dendritic BDNF application caused an immediate and 
      robust induction of LTP. LTP induction required activation of postsynaptic Ca2+ 
      channels and N-methyl-d-aspartate receptors and was prevented by the blockage of 
      postsynaptic Ca2+ transients. Thus, our results suggest that BDNF-mediated LTP is 
      induced postsynaptically. Our finding that dendritic spines are the exclusive 
      synaptic sites for rapid BDNF-evoked Ca2+ signaling supports this conclusion.
FAU - Kovalchuk, Yury
AU  - Kovalchuk Y
AD  - Institut fur Physiologie, Ludwig-Maximilians Universitat Munchen, 80336 Munchen, 
      Germany.
FAU - Hanse, Eric
AU  - Hanse E
FAU - Kafitz, Karl W
AU  - Kafitz KW
FAU - Konnerth, Arthur
AU  - Konnerth A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - SY7Q814VUP (Calcium)
SB  - IM
CIN - Science. 2002 Mar 1;295(5560):1651-3. PMID: 11872822
MH  - Action Potentials
MH  - Animals
MH  - Axons/drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/pharmacology/*physiology
MH  - Calcium/metabolism
MH  - Calcium Signaling
MH  - Dendrites/drug effects/*physiology
MH  - Dentate Gyrus/*cytology/drug effects/physiology
MH  - Excitatory Postsynaptic Potentials
MH  - In Vitro Techniques
MH  - *Long-Term Potentiation/drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neurons/drug effects/physiology
MH  - Patch-Clamp Techniques
MH  - Perforant Pathway
MH  - Receptor, trkB/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Synapses/drug effects/*physiology
EDAT- 2002/03/02 10:00
MHDA- 2002/03/28 10:01
CRDT- 2002/03/02 10:00
PHST- 2002/03/02 10:00 [pubmed]
PHST- 2002/03/28 10:01 [medline]
PHST- 2002/03/02 10:00 [entrez]
AID - 295/5560/1729 [pii]
AID - 10.1126/science.1067766 [doi]
PST - ppublish
SO  - Science. 2002 Mar 1;295(5560):1729-34. doi: 10.1126/science.1067766.