PMID- 11873072
OWN - NLM
STAT- MEDLINE
DCOM- 20020405
LR  - 20200930
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 29
IP  - 3
DP  - 2002 Mar 1
TI  - Concordance between HIV source partner identification and molecular confirmation 
      in acute retroviral syndrome.
PG  - 232-43
AB  - Most HIV-1 transmission studies use self-reported history to define the source 
      contact. To evaluate the reliability of epidemiologic source partner reporting, 
      heteroduplex mobility assays (HMAs) were performed comparing the different viral 
      strains present in the partners. Partners were typed for human leukocyte antigen 
      (HLA) to evaluate the degree of shared alleles. Of 11 couples evaluated, HMA 
      analysis confirmed nine transmissions (including 1 oral-genital transmission), 
      indicated probable transmission in 1 couple, and suggested an alternative source 
      partner in another. Nine source partners transmitted a major variant. Four source 
      partners knew their HIV status. Previous HIV monitoring was reported by 5 of the 
      6 confirmed source partners who were unaware of their HIV status at the time of 
      transmission. We also evaluated potential "sharing of HLA alleles" as a risk 
      factor for HIV-1 acquisition; partners were not found to have a higher degree of 
      shared HLA alleles. Lack of awareness about infection status as a consequence of 
      infrequent testing plays a major role in the secondary transmission of HIV. These 
      findings re-emphasize the importance of using safe sex practices at all times.
FAU - Truong, Hong-Ha M
AU  - Truong HM
AD  - Department of Pathobiology, University of Washington, Seattle, Washington, USA.
FAU - Berrey, M Michelle
AU  - Berrey MM
FAU - Shea, Theresa
AU  - Shea T
FAU - Diem, Kurt
AU  - Diem K
FAU - Corey, Lawrence
AU  - Corey L
LA  - eng
GR  - 1 U01 AI-41535/AI/NIAID NIH HHS/United States
GR  - AI-07140/AI/NIAID NIH HHS/United States
GR  - AI-31448/AI/NIAID NIH HHS/United States
GR  - AI-43650/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - *Contact Tracing
MH  - Female
MH  - HIV Infections/epidemiology/*transmission/virology
MH  - *HIV-1/classification/genetics/isolation & purification
MH  - HLA Antigens/genetics
MH  - Heteroduplex Analysis
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Molecular Epidemiology
MH  - *Sexual Partners
EDAT- 2002/03/02 10:00
MHDA- 2002/04/06 10:01
CRDT- 2002/03/02 10:00
PHST- 2002/03/02 10:00 [pubmed]
PHST- 2002/04/06 10:01 [medline]
PHST- 2002/03/02 10:00 [entrez]
AID - 10.1097/00042560-200203010-00003 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2002 Mar 1;29(3):232-43. doi: 
      10.1097/00042560-200203010-00003.