PMID- 11873624
OWN - NLM
STAT- MEDLINE
DCOM- 20020419
LR  - 20191105
IS  - 0369-8114 (Print)
IS  - 0369-8114 (Linking)
VI  - 50
IP  - 1
DP  - 2002 Feb
TI  - [Clinical and serological characteristics of systemic lupus erythematosus: 128 
      cases].
PG  - 18-24
AB  - OBJECTIVE: To analyse the clinical and serological characteristics of systemic 
      lupus erythematosus (SLE) in the center of Tunisia. METHODS: We studied 128 
      patients with SLE aged one to 73 years. Antinuclear antibodies (ANA) were 
      detected by an immunofluorescence method. Anti-double-stranded DNA (anti-dsDNA) 
      antibodies, anti-extractable nuclear antigen antibodies (anti-Sm, anti-SS-A, 
      anti-SS-B and anti-RNP) and anti-cardiolipin (aCL of IgG, IgA and IgM isotypes) 
      antibodies were detected by ELISA. RESULTS: Malar rash (71%) and anemia (71%) 
      were the most common clinical manifestations. Arthritis was seen in 62.5%. Severe 
      kidney damage was observed in 39%. Pericarditis and pleuritis were observed in 
      only 23%. Neurological manifestations (16%) were uncommon. Clinical 
      manifestations of anti-phospholipid syndrome (SAPL) were observed in 15%. ANA 
      were detected in 100%, anti-dsDNA in 76%, anti-Sm in 55.5%, anti-SS-A in 64%, 
      anti-SS-B in 33.6%, anti-RNP in 49%. aCL of IgG, IgA and IgM isotypes were 
      detected in 63.5%, 49% and 40.6% of the patients respectively. The only 
      significant positive clinical associations were those of arthritis with 
      anti-dsDNA antibodies (p = 0.022) and malar rash with anti-SS-A antibodies (p = 
      0.002). CONCLUSIONS: This study suggests that tunisians with SLE present, in 
      general, a mild form of disease predominantly manifested by cutaneous, 
      musculoskeletal and hematologic involvement but low prevalence of major organ 
      damage.
FAU - Ghedira, I
AU  - Ghedira I
AD  - Laboratoire de microbiologie-immunologie, CHU Farhat Hached, avenue Ibn El 
      Jazzar, 4000, Sousse, Tunisie. Ibtissem.Ghedira@fphm.rnu.tn
FAU - Sakly, W
AU  - Sakly W
FAU - Jeddi, M
AU  - Jeddi M
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Caracteristiques cliniques et serologiques du lupus erythemateux systemique: a 
      propos de 128 cas.
PL  - France
TA  - Pathol Biol (Paris)
JT  - Pathologie-biologie
JID - 0265365
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Antinuclear/blood
MH  - Autoantibodies/blood
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Lupus Erythematosus, Systemic/blood/diagnosis/*immunology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2002/03/05 10:00
MHDA- 2002/04/20 10:01
CRDT- 2002/03/05 10:00
PHST- 2002/03/05 10:00 [pubmed]
PHST- 2002/04/20 10:01 [medline]
PHST- 2002/03/05 10:00 [entrez]
AID - S0369-8114(01)00262-0 [pii]
AID - 10.1016/s0369-8114(01)00262-0 [doi]
PST - ppublish
SO  - Pathol Biol (Paris). 2002 Feb;50(1):18-24. doi: 10.1016/s0369-8114(01)00262-0.