PMID- 11874523
OWN - NLM
STAT- MEDLINE
DCOM- 20020411
LR  - 20190922
IS  - 0140-7783 (Print)
IS  - 0140-7783 (Linking)
VI  - 25
IP  - 1
DP  - 2002 Feb
TI  - Serum pharmacokinetics and tissue and milk residues of oxytetracycline in goats 
      following a single intramuscular injection of a long-acting preparation and milk 
      residues following a single subcutaneous injection.
PG  - 25-32
AB  - Separate groups of goats were used to determine drug depletion patterns in serum 
      (n=10), tissue (n=20) and milk (n=8) following a single intramuscular (i.m.) dose 
      of 20 mg/kg of a long-acting oxytetracycline (OTC) formulation (Liquamycin 
      LA-200). Milk residues were also determined following a subcutaneous (s.c.) 
      administration of the same product at the same dose. Serum samples were taken for 
      24 h post-treatment and tissues (fat, liver, kidney, muscle and injection site) 
      collected at 4, 7, 14, 21 and 28 days following injection. Milk from lactating 
      goats was collected every 12 h for 8 days following both the i.m. and s.c. 
      treatments utilizing an intervening 5-week washout period. Residues in serum and 
      tissue were measured using a microbial inhibition assay, while milk residues were 
      measured using both a microbial inhibition assay and a validated HPLC method. The 
      serum pharmacokinetic parameters of OTC in goats were determined, with a mean 
      AUC=67.4 microg h/mL, mean terminal half-life=14.4 h, and apparent clearance=0.33 
      L/kg h. Tissue half-lives could not be determined with confidence because the 
      collection times provided only two points at which residues could be measured for 
      most tissues. Oxytetracycline residues in all goat tissue samples measured less 
      then cattle tissue tolerance by 96 h postdosing. One-compartment model describing 
      milk depletion data for i.m. and s.c. dosing had terminal slope half-lives of 
      20.1 and 36.1 h, respectively. By 96 h post-treatment none of the milk samples 
      contained OTC residues in excess of the cattle milk tolerance (0.3 p.p.m.). For 
      both milk and tissue, the upper-bound 99% confidence intervals for the samples 
      taken from goats 96 h postdosing were lower than approved cow milk and tissue 
      tolerances.
FAU - Payne, M A
AU  - Payne MA
AD  - Environmental Toxicology Extension, University of California, Davis, CA 
      95616-8588, USA. mpayne@ucdavis.edu
FAU - Babish, J G
AU  - Babish JG
FAU - Bulgin, M
AU  - Bulgin M
FAU - Lane, M
AU  - Lane M
FAU - Wetzlich, S
AU  - Wetzlich S
FAU - Craigmill, A L
AU  - Craigmill AL
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - J Vet Pharmacol Ther
JT  - Journal of veterinary pharmacology and therapeutics
JID - 7910920
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - X20I9EN955 (Oxytetracycline)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/administration & dosage/blood/*pharmacokinetics
MH  - Area Under Curve
MH  - Chromatography, High Pressure Liquid/veterinary
MH  - Delayed-Action Preparations
MH  - Drug Residues/pharmacokinetics
MH  - Female
MH  - Goats/*metabolism
MH  - Injections, Intramuscular/veterinary
MH  - Injections, Subcutaneous/veterinary
MH  - Milk/*metabolism
MH  - Oxytetracycline/administration & dosage/blood/*pharmacokinetics
MH  - Tissue Distribution
EDAT- 2002/03/05 10:00
MHDA- 2002/04/12 10:01
CRDT- 2002/03/05 10:00
PHST- 2002/03/05 10:00 [pubmed]
PHST- 2002/04/12 10:01 [medline]
PHST- 2002/03/05 10:00 [entrez]
AID - 378 [pii]
AID - 10.1046/j.1365-2885.2002.00378.x [doi]
PST - ppublish
SO  - J Vet Pharmacol Ther. 2002 Feb;25(1):25-32. doi: 
      10.1046/j.1365-2885.2002.00378.x.