PMID- 11874884
OWN - NLM
STAT- MEDLINE
DCOM- 20020611
LR  - 20190508
IS  - 1071-412X (Print)
IS  - 1098-6588 (Electronic)
IS  - 1071-412X (Linking)
VI  - 9
IP  - 2
DP  - 2002 Mar
TI  - Neutralizing antibody responses to human herpesviruses 6 and 7 do not cross-react 
      with each other, and maternal neutralizing antibodies contribute to sequential 
      infection with these viruses in childhood.
PG  - 388-93
AB  - Seroprevalence of human herpesvirus 6 (HHV-6) and HHV-7 infections is very high 
      throughout the world, and almost all people are exposed first to HHV-6 and second 
      to HHV-7 in their childhood. However, it is not clear whether the neutralizing 
      (NT) antibody response between each virus is cross-reactive or not. To elucidate 
      the NT antibody response between each virus, 55 serum samples from an adult group 
      (subjects 22 to 88 years old) and 60 serum samples from a young group (subjects 2 
      to 18 years old) were examined by a dot blot method for detecting viral late 
      antigen. Thirty-nine serum samples obtained from cord bloods and a few serum 
      samples obtained from pediatric patients with exanthem subitum were also examined 
      to assess the maternal transferred NT antibodies against each virus. The NT 
      antibody titers against HHV-7 in the adult group remained high throughout all the 
      individuals, and none were negative. Those against HHV-6 were high values in the 
      young group but low values, including negative values (three samples), in the 
      adult group. These results suggested that the NT antibody response to either 
      HHV-6 or HHV-7 in each individual was specific to each virus and did not 
      cross-react with each other. In the adult group, the NT antibody response to 
      HHV-6 decreased, while that to HHV-7 remained high throughout all the 
      individuals. Maternal transferred NT antibody titers against HHV-7 were higher 
      and remained longer after birth than those of HHV-6, and these findings were in 
      accord with the clinical observation that HHV-6 infection usually occurs earlier 
      than HHV-7 infection.
FAU - Yoshida, Mariko
AU  - Yoshida M
AD  - Department of Virology, Okayama University Graduate School of Medicine and 
      Dentistry, Okayama, Japan. mariko@md.okayama-u.ac.jp
FAU - Torigoe, Sadayoshi
AU  - Torigoe S
FAU - Ikeue, Kumiko
AU  - Ikeue K
FAU - Yamada, Masao
AU  - Yamada M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Diagn Lab Immunol
JT  - Clinical and diagnostic laboratory immunology
JID - 9421292
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Viral/blood/*immunology
MH  - Antibody Specificity
MH  - Child
MH  - Child, Preschool
MH  - Cross Reactions
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Exanthema Subitum/*immunology
MH  - Herpesvirus 6, Human/*immunology
MH  - Herpesvirus 7, Human/*immunology
MH  - Humans
MH  - Immunity, Maternally-Acquired/immunology
MH  - Infant
MH  - Infant, Newborn
MH  - Middle Aged
MH  - Neutralization Tests
MH  - Roseolovirus Infections/*immunology
PMC - PMC119946
EDAT- 2002/03/05 10:00
MHDA- 2002/06/12 10:01
PMCR- 2002/03/01
CRDT- 2002/03/05 10:00
PHST- 2002/03/05 10:00 [pubmed]
PHST- 2002/06/12 10:01 [medline]
PHST- 2002/03/05 10:00 [entrez]
PHST- 2002/03/01 00:00 [pmc-release]
AID - 0213 [pii]
AID - 10.1128/cdli.9.2.388-393.2002 [doi]
PST - ppublish
SO  - Clin Diagn Lab Immunol. 2002 Mar;9(2):388-93. doi: 10.1128/cdli.9.2.388-393.2002.