PMID- 11874925
OWN - NLM
STAT- MEDLINE
DCOM- 20020510
LR  - 20190515
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 25
IP  - 3
DP  - 2002 Mar
TI  - Effect of a high-protein, high-monounsaturated fat weight loss diet on glycemic 
      control and lipid levels in type 2 diabetes.
PG  - 425-30
AB  - OBJECTIVE: To determine the effect of a high-protein (HP) weight loss diet 
      compared with a lower-protein (LP) diet on fat and lean tissue and fasting and 
      postprandial glucose and insulin concentrations. RESEARCH DESIGN AND METHODS: 
      Replacing dietary protein for carbohydrate (CHO) during energy restriction and 
      weight loss has been effective in sparing lean mass and improving insulin 
      sensitivity in obese subjects but has not been tested in subjects with type 2 
      diabetes. We compared an HP diet (28% protein, 42% CHO, 28% fat [8% saturated 
      fatty acids, 12% monounsaturated fatty acids, 5% polyunsaturated fatty acids]) 
      with an LP diet (16% protein, 55% CHO, 26% fat [8% saturated fatty acids, 11% 
      monounsaturated fatty acids, 5% polyunsaturated fatty acids]) in 54 obese men and 
      women with type 2 diabetes during 8 weeks of energy restriction (1,600 kcal) and 
      4 weeks of energy balance. Body composition was determined by dual-energy X-ray 
      absorptiometry at weeks 0 and 12. RESULTS: Overall, weight loss of 5.2 +/- 1.8 kg 
      was achieved independently of diet composition. However, women on the HP diet 
      lost significantly more total (5.3 vs. 2.8 kg, P=0.009) and abdominal (1.3 vs. 
      0.7 kg, P=0.006) fat compared with the women on the LP diet, whereas, in men, 
      there was no difference in fat loss between diets (3.9 vs. 5.1 kg). Total lean 
      mass decreased in all subjects independently of diet composition. LDL cholesterol 
      reduction was significantly greater on the HP diet (5.7%) than on the LP diet 
      (2.7%) (P < 0.01). CONCLUSIONS: Both dietary patterns resulted in improvements in 
      the cardiovascular disease (CVD) risk profile as a consequence of weight loss. 
      However, the greater reductions in total and abdominal fat mass in women and 
      greater LDL cholesterol reduction observed in both sexes on the HP diet suggest 
      that it is a valid diet choice for reducing CVD risk in type 2 diabetes.
FAU - Parker, Barbara
AU  - Parker B
AD  - CSIRO Health Sciences and Nutrition, Adelaide, Australia.
FAU - Noakes, Manny
AU  - Noakes M
FAU - Luscombe, Natalie
AU  - Luscombe N
FAU - Clifton, Peter
AU  - Clifton P
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Dietary Proteins)
RN  - 0 (Fatty Acids, Monounsaturated)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adipose Tissue/anatomy & histology
MH  - Blood Glucose/drug effects/*metabolism
MH  - Body Composition
MH  - Cholesterol, LDL/blood
MH  - Diabetes Mellitus/blood/*diet therapy/physiopathology
MH  - Diabetes Mellitus, Type 2/blood/*physiopathology
MH  - *Dietary Fats, Unsaturated/*pharmacology
MH  - *Dietary Proteins
MH  - Energy Intake
MH  - Energy Metabolism
MH  - Fatty Acids, Monounsaturated/*pharmacology
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Insulin/administration & dosage/pharmacology
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - *Obesity
MH  - Weight Loss/*drug effects
EDAT- 2002/03/05 10:00
MHDA- 2002/05/11 10:01
CRDT- 2002/03/05 10:00
PHST- 2002/03/05 10:00 [pubmed]
PHST- 2002/05/11 10:01 [medline]
PHST- 2002/03/05 10:00 [entrez]
AID - 10.2337/diacare.25.3.425 [doi]
PST - ppublish
SO  - Diabetes Care. 2002 Mar;25(3):425-30. doi: 10.2337/diacare.25.3.425.