PMID- 11875574
OWN - NLM
STAT- MEDLINE
DCOM- 20020329
LR  - 20220227
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 415
IP  - 6875
DP  - 2002 Feb 28
TI  - Characterization of a common precursor population for dendritic cells.
PG  - 1043-7
AB  - Dendritic cells (DCs) are essential for the establishment of immune responses 
      against pathogens and tumour cells, and thus have great potential as tools for 
      vaccination and cancer immunotherapy trials. Experimental evidence has led to a 
      dual DC differentiation model, which involves the existence of both myeloid- and 
      lymphoid-derived DCs. But this concept has been challenged by recent reports 
      demonstrating that both CD8- and CD8+ DCs, considered in mice as archetypes of 
      myeloid and lymphoid DCs respectively, can be generated from either lymphoid or 
      myeloid progenitors. The issue of DC physiological derivation therefore remains 
      an open question. Here we report the characterization of a DC-committed precursor 
      population, which has the capacity to generate all the DC subpopulations present 
      in mouse lymphoid organs---including CD8- and CD8+ DCs, as well as the B220+ DC 
      subset---but which is devoid of myeloid or lymphoid differentiation potential. 
      These data support an alternative model of DC development, in which there is an 
      independent, common DC differentiation pathway.
FAU - del Hoyo, Gloria Martinez
AU  - del Hoyo GM
AD  - Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, 
      Spain.
FAU - Martin, Pilar
AU  - Martin P
FAU - Vargas, Hector Hernandez
AU  - Vargas HH
FAU - Ruiz, Sara
AU  - Ruiz S
FAU - Arias, Cristina Fernandez
AU  - Arias CF
FAU - Ardavin, Carlos
AU  - Ardavin C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Antigens, CD)
RN  - 0 (Integrin alphaXbeta2)
RN  - 0 (Interferon Type I)
SB  - IM
EIN - Nature. 2004 May 13;429(6988):205
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - Bone Marrow Cells/cytology
MH  - Cell Differentiation/physiology
MH  - Dendritic Cells/*cytology/immunology/ultrastructure
MH  - Immunophenotyping
MH  - Integrin alphaXbeta2/metabolism
MH  - Interferon Type I/biosynthesis
MH  - Lymph Nodes/immunology
MH  - Mammary Tumor Virus, Mouse/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Retroviridae Infections/immunology
MH  - Spleen/cytology
MH  - Stem Cells/*cytology/immunology
MH  - Thymus Gland/cytology
EDAT- 2002/03/05 10:00
MHDA- 2002/03/30 10:01
CRDT- 2002/03/05 10:00
PHST- 2002/03/05 10:00 [pubmed]
PHST- 2002/03/30 10:01 [medline]
PHST- 2002/03/05 10:00 [entrez]
AID - 4151043a [pii]
AID - 10.1038/4151043a [doi]
PST - ppublish
SO  - Nature. 2002 Feb 28;415(6875):1043-7. doi: 10.1038/4151043a.