PMID- 11876587
OWN - NLM
STAT- MEDLINE
DCOM- 20020823
LR  - 20190716
IS  - 0001-6489 (Print)
IS  - 0001-6489 (Linking)
VI  - 122
IP  - 1
DP  - 2002 Jan
TI  - Brain-derived neurotrophic factor and nitric oxide synthase inhibitor protect the 
      vestibular organ against gentamicin ototoxicity.
PG  - 10-5
AB  - In order to find a way to develop a new treatment for inner ear disorders, the 
      effects of a nitric oxide synthase (NOS) inhibitor [N-nitro-L-arginine 
      methylester (L-NAME)] and a neurotrophin [brain-derived neurotrophic factor 
      (BDNF)] were investigated. The effect of L-NAME and BDNF on gentamicin-induced 
      vestibular hair cell damage was investigated by using the in vitro LIVE/DEAD 
      system. Both L-NAME and BDNF individually reduced the vestibular hair cell damage 
      caused by gentamicin but the combination of L-NAME and BDNF was more successful 
      in preventing damage. It is therefore suggested that treatment with a combination 
      of an NOS inhibitor and a neurotrophin will help us to treat inner ear disorders.
FAU - Takumida, Masaya
AU  - Takumida M
AD  - Department of Otolaryngology, Hiroshima University Faculty of Medicine, Japan. 
      masati@hiroshima-u.ac.jp
FAU - Anniko, Matti
AU  - Anniko M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Gentamicins)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*toxicity
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cell Survival/drug effects
MH  - Enzyme Inhibitors/*pharmacology
MH  - Gentamicins/*toxicity
MH  - Guinea Pigs
MH  - Hair Cells, Vestibular/*drug effects
MH  - NG-Nitroarginine Methyl Ester/*pharmacology
MH  - Vestibule, Labyrinth/*drug effects
EDAT- 2002/03/06 10:00
MHDA- 2002/08/24 10:01
CRDT- 2002/03/06 10:00
PHST- 2002/03/06 10:00 [pubmed]
PHST- 2002/08/24 10:01 [medline]
PHST- 2002/03/06 10:00 [entrez]
AID - 10.1080/00016480252775661 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2002 Jan;122(1):10-5. doi: 10.1080/00016480252775661.