PMID- 11876972
OWN - NLM
STAT- MEDLINE
DCOM- 20031030
LR  - 20061115
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 21
IP  - 3
DP  - 2000 Mar
TI  - [Relationship between human herpesvirus 6 infection and idiopathic 
      thrombocytopenic purpura].
PG  - 135-7
AB  - OBJECTIVE: To investigate the pathogenic role of human herpesvirus 6 (HHV-6) in 
      idiopathic thrombocytopenic purpura (ITP). METHODS: HHV-6 DNA was examined by 
      polymerase chain reaction (PCR) in bone marrow mononuclear cells (BMMNC) of 105 
      ITP patients. Human cytomegalovirus (HCMV) and parvovirus B(19) DNA were also 
      examined in some cases. Platelet-associated antibodies (PAIg) were measured by 
      competitive ELISA in 66 ITP patients. Serum IgG titer to HHV-6 was observed by 
      indirect immunofluorescence assay in 19 ITP patients. RESULTS: (1) HHV-6 DNA 
      positivity was 41.0% for ITP patients, significantly higher than that for control 
      group (P < 0.05). HHV-6 DNA positivity for adult ITP patients, especially adult 
      chronic cases was significantly higher than that for childhood patients (P < 
      0.025). Positivities for parvovirus B(19) and HCMV DNA were 24.1% and 9.7%, 
      respectively. (2) HHV-6 DNA positivity for patients with abnormal level of PAIgG 
      was significantly higher than that for patients with normal level of PAIgG (P < 
      0.05). (3) Patients coinfected with HHV-6 and B(19) or HCMV had more severe 
      symptoms or poorer prognosis. CONCLUSION: HHV-6 infection might be associated 
      with excessive PAIgG. Coinfection with HHV-6, B(19) or HCMV may cause more severe 
      symptoms in ITP patients.
FAU - Ma, X
AU  - Ma X
AD  - Institute of Hematology, CAMS and PUMC, Tianjin 300020, China.
FAU - Lu, D
AU  - Lu D
FAU - Song, Y
AU  - Song Y
FAU - Mu, G
AU  - Mu G
FAU - Ji, L
AU  - Ji L
FAU - Li, G
AU  - Li G
FAU - Lin, Y
AU  - Lin Y
FAU - Yang, R
AU  - Yang R
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Viral/blood
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus/isolation & purification
MH  - DNA, Viral/analysis
MH  - Female
MH  - Herpesvirus 6, Human/genetics/immunology/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parvovirus B19, Human/isolation & purification
MH  - Purpura, Thrombocytopenic, Idiopathic/*etiology
MH  - Roseolovirus Infections/*complications
EDAT- 2002/03/06 10:00
MHDA- 2003/10/31 05:00
CRDT- 2002/03/06 10:00
PHST- 2002/03/06 10:00 [pubmed]
PHST- 2003/10/31 05:00 [medline]
PHST- 2002/03/06 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2000 Mar;21(3):135-7.