PMID- 11877170
OWN - NLM
STAT- MEDLINE
DCOM- 20030821
LR  - 20061115
IS  - 0412-4081 (Print)
IS  - 0412-4081 (Linking)
VI  - 34
IP  - 2
DP  - 1998 Mar
TI  - [The determination of neuron-specific enolase of serum in the diagnosis and 
      supervision of retinoblastoma].
PG  - 117-20
AB  - OBJECTIVE: To investigate the value of determining quantity of neuron-specific 
      enolase (NSE) in the diagnosis and supervision in patients with retinoblastoma 
      (Rb). METHOD: We used rapid electrophoretic and the fluorometer method in the 35 
      serum specimens from 35 patients with Rb during surgery, after enucleation, 
      respectively, at 3, 6, 12, >or= 18 months and 31 serum specimens from 31 control 
      cases to determine the quantity of NSE and enolase isoenzymes. RESULTS: There 
      were 207 +/- 65.9 u/L of all isoenzymes and 98.4 +/- 40.3 u/L of NSE from 35 
      patients with Rb. In comparison with the levels of control cases (respectively, 
      140.7 +/- 46.0 U//L of all isoenzymes, 41 +/- 10.9 u/L of NSE), both serum levels 
      in patients with Rb increased obviously, the difference being significant. At 6, 
      12, and >or= 18 months after surgery, the determinations of all isoenzymes and 
      NSE from 35 patients with Rb decreased step by step, the difference being 
      significant in comparison with the values before the surgery. After surgery >or= 
      18 months, the levels of NSE and all enolase decreased to that of NSE and all 
      enolase from control cases. CONCLUSION: The determination of enolase level, 
      especially NSE of serum, is valuable for the diagnosis of patients with Rb.
FAU - Wu, Z
AU  - Wu Z
AD  - Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, 
      Guangzhou 510060.
FAU - Mao, Y
AU  - Mao Y
FAU - Yang, H
AU  - Yang H
FAU - Pan, S
AU  - Pan S
FAU - Chen, Z
AU  - Chen Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yan Ke Za Zhi
JT  - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
JID - 16210540R
RN  - 0 (Isoenzymes)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Isoenzymes/blood
MH  - Phosphopyruvate Hydratase/*blood
MH  - Retinal Neoplasms/blood/*diagnosis/surgery
MH  - Retinoblastoma/blood/*diagnosis/surgery
EDAT- 2002/03/06 10:00
MHDA- 2003/08/22 05:00
CRDT- 2002/03/06 10:00
PHST- 2002/03/06 10:00 [pubmed]
PHST- 2003/08/22 05:00 [medline]
PHST- 2002/03/06 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Yan Ke Za Zhi. 1998 Mar;34(2):117-20.