PMID- 11880156
OWN - NLM
STAT- MEDLINE
DCOM- 20020418
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 123
IP  - 1-2
DP  - 2002 Feb
TI  - Activation of Vbeta8 T cells affects spontaneous EAE in MBP TCR transgenic mice.
PG  - 112-22
AB  - Two strains of transgenic (Tg) mice (Valpha2.3/Vbeta8.2 and Valpha4/Vbeta8.2) 
      have T cell receptors (TCR) that recognize the NAc1-11 immunodominant epitope of 
      the myelin basic protein (MBP). Spontaneous experimental autoimmune 
      encephalomyelitis (sEAE) readily develops in Valpha2.3/Vbeta8.2 mice. T cells in 
      Valpha2.3/Vbeta8.2 mice demonstrate increased levels of CD69, CD44(high) and 
      decreased CD45RB relative to Valpha4/Vbeta8.2 mice. Increased proliferative 
      responses to MBP and high levels of TNF-alpha are seen in Valpha2.3/Vbeta8.2 
      mice. High IL-4 and TGF-beta production is observed in Valpha4/Vbeta8.2 mice. CC 
      chemokines (macrophage inflammatory protein-1 alpha (MIP-1alpha), RANTES and 
      monocyte chemotactic protein 1 (MCP-1)) are increased in the central nervous 
      system (CNS) of Valpha2.3/Vbeta8.2 mice. Thus, activated Th1 cells in the 
      periphery of Valpha2.3/Vbeta8.2 mice may traffic to the CNS in response to CC 
      chemokines, influencing sEAE.
FAU - Song, Fei
AU  - Song F
AD  - Department of Molecular Virology, Immunology and Medical Genetics, College of 
      Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA.
FAU - Gienapp, Ingrid E
AU  - Gienapp IE
FAU - Wang, Xianming
AU  - Wang X
FAU - Whitacre, Caroline C
AU  - Whitacre CC
LA  - eng
GR  - AI35960/AI/NIAID NIH HHS/United States
GR  - NS23561/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD69 antigen)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
SB  - IM
MH  - Animals
MH  - Antigens, CD/analysis
MH  - Antigens, Differentiation, T-Lymphocyte/analysis
MH  - Chemokines/biosynthesis
MH  - Cytokines/biosynthesis
MH  - Encephalomyelitis, Autoimmune, Experimental/*etiology
MH  - Lectins, C-Type
MH  - *Lymphocyte Activation
MH  - Mice
MH  - Mice, Transgenic
MH  - Myelin Basic Protein/*physiology
MH  - Receptors, Antigen, T-Cell, alpha-beta/*analysis
MH  - T-Lymphocytes/*immunology
EDAT- 2002/03/07 10:00
MHDA- 2002/04/19 10:01
CRDT- 2002/03/07 10:00
PHST- 2002/03/07 10:00 [pubmed]
PHST- 2002/04/19 10:01 [medline]
PHST- 2002/03/07 10:00 [entrez]
AID - S0165572801004945 [pii]
AID - 10.1016/s0165-5728(01)00494-5 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2002 Feb;123(1-2):112-22. doi: 10.1016/s0165-5728(01)00494-5.