PMID- 11880160
OWN - NLM
STAT- MEDLINE
DCOM- 20020418
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 123
IP  - 1-2
DP  - 2002 Feb
TI  - Interferon-beta increases the stimulatory capacity of monocyte-derived dendritic 
      cells to induce IL-13, IL-5 and IL-10 in autologous T-cells.
PG  - 160-9
AB  - Dendritic cells (DCs) are key regulators of immune responses and have been 
      associated with autoimmunity in animal models and human disease. The effects of 
      interferon beta (IFN-beta), an immunomodulatory cytokine used in multiple 
      sclerosis (MS) therapy, on DCs are not well understood. Monocyte-derived DCs at 
      different stages of maturation were stimulated with IFN-beta and DC-phenotype and 
      stimulatory function were measured. IFN-beta inhibited the development of DCs at 
      early stages but enhanced DC maturation. Moreover, IFN-beta enhanced the capacity 
      of DCs to stimulate autologous T-cells to secrete IL-13, IL-10 and IL-5. Thus, 
      IFN-beta has both immunostimulatory and immunosuppressive effects on DCs 
      depending on the stage of maturation.
FAU - Wiesemann, Elke
AU  - Wiesemann E
AD  - Department of Neurology, Medical School Hannover, Carl-Neuberg-Strasse 1, 
      D-30623, Hannover, Germany.
FAU - Sonmez, Daniela
AU  - Sonmez D
FAU - Heidenreich, Fedor
AU  - Heidenreich F
FAU - Windhagen, Anja
AU  - Windhagen A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1a antigen)
RN  - 0 (Integrin alphaXbeta2)
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-5)
RN  - 0 (Receptors, Interferon)
RN  - 130068-27-8 (Interleukin-10)
RN  - 77238-31-4 (Interferon-beta)
SB  - IM
MH  - Antigens, CD1/biosynthesis
MH  - Dendritic Cells/*drug effects/physiology
MH  - Humans
MH  - Integrin alphaXbeta2/biosynthesis
MH  - Interferon-beta/*pharmacology
MH  - Interleukin-10/*biosynthesis
MH  - Interleukin-13/*biosynthesis
MH  - Interleukin-5/*biosynthesis
MH  - Monocytes/*physiology
MH  - Receptors, Interferon/analysis
MH  - T-Lymphocytes/*metabolism
EDAT- 2002/03/07 10:00
MHDA- 2002/04/19 10:01
CRDT- 2002/03/07 10:00
PHST- 2002/03/07 10:00 [pubmed]
PHST- 2002/04/19 10:01 [medline]
PHST- 2002/03/07 10:00 [entrez]
AID - S0165572801004829 [pii]
AID - 10.1016/s0165-5728(01)00482-9 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2002 Feb;123(1-2):160-9. doi: 10.1016/s0165-5728(01)00482-9.