PMID- 11880161
OWN - NLM
STAT- MEDLINE
DCOM- 20020418
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 123
IP  - 1-2
DP  - 2002 Feb
TI  - Interferon beta-1b modulates MCP-1 expression and production in 
      relapsing-remitting multiple sclerosis.
PG  - 170-9
AB  - Monocyte chemoattractant protein-1 (MCP-1) seems to be involved in the 
      pathogenesis of multiple sclerosis (MS). We found that in unstimulated (PHA(-)) 
      and PHA-stimulated (PHA(+)) peripheral blood mononuclear cells (PBMC), MCP-1 and 
      TNFalpha levels are higher in stable untreated MS patients. Interferon gamma 
      (IFNgamma) is higher in relapsing patients in PHA(-) cultures and in stable 
      patients in PHA(+) cultures. Chronic IFNbeta-1b treatment down-regulates 
      TNFalpha, IFNgamma and MCP-1 production except for TNFalpha in relapsing 
      patients. IFNbeta-1b, in vitro, increases MCP-1, TNFalpha and IFNgamma 
      spontaneous production in all patients. Multivariate analysis suggests that MCP-1 
      production is dependent from clinical status and not from TNFalpha and IFNgamma 
      production. Logistic regression analysis shows that MCP-1 production is 
      significantly modified by treatment. Further studies are needed to clarify the 
      role of MCP-1 in MS.
FAU - Iarlori, Carla
AU  - Iarlori C
AD  - Department of Oncology and Neuroscience, Neuroimmunology Unit, University "G. 
      d'Annunzio", Via dei Vestini, I-66013, Chieti, Italy.
FAU - Reale, Marcella
AU  - Reale M
FAU - De Luca, Giovanna
AU  - De Luca G
FAU - Di Iorio, Angelo
AU  - Di Iorio A
FAU - Feliciani, Claudio
AU  - Feliciani C
FAU - Tulli, Antonio
AU  - Tulli A
FAU - Conti, Pio
AU  - Conti P
FAU - Gambi, Domenico
AU  - Gambi D
FAU - Lugaresi, Alessandra
AU  - Lugaresi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
RN  - 145155-23-3 (Interferon beta-1b)
RN  - 77238-31-4 (Interferon-beta)
RN  - XRO4566Q4R (Interferon beta-1a)
SB  - IM
MH  - Adult
MH  - Cells, Cultured
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Female
MH  - Humans
MH  - Interferon beta-1a
MH  - Interferon beta-1b
MH  - Interferon-beta/*pharmacology
MH  - Leukocytes, Mononuclear/metabolism
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*immunology
MH  - Multivariate Analysis
MH  - RNA, Messenger/analysis
MH  - Recurrence
EDAT- 2002/03/07 10:00
MHDA- 2002/04/19 10:01
CRDT- 2002/03/07 10:00
PHST- 2002/03/07 10:00 [pubmed]
PHST- 2002/04/19 10:01 [medline]
PHST- 2002/03/07 10:00 [entrez]
AID - S0165572801004878 [pii]
AID - 10.1016/s0165-5728(01)00487-8 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2002 Feb;123(1-2):170-9. doi: 10.1016/s0165-5728(01)00487-8.