PMID- 11882354
OWN - NLM
STAT- MEDLINE
DCOM- 20020418
LR  - 20220318
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 172
IP  - 2
DP  - 2002 Mar 20
TI  - Free radical scavenging activity of red ginseng aqueous extracts.
PG  - 149-56
AB  - This study was performed to investigate the free radical scavenging activity of 
      Panax red ginseng C.A. Meyer aqueous extract on 1,1-dipheny-2-picrylhydrazyl 
      (DPPH), carbon-centered radical, hydroxyl and superoxide radicals using Electron 
      Spin Resonance (ESR) spectrometer and spin-trapping techniques. Two different Red 
      ginseng aqueous extracts prepared by boiling water or room temperature extraction 
      exhibited no significant difference in free radical scavenging activity. Ginseng 
      extracts completely eliminated DPPH radical at 2 mg/ml. About 0.5 mg/ml ginseng 
      extracts quenched 80% carbon-centered free radicals generated from 
      2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). Hydroxyl radical and 
      superoxide radical were generated by UV irradiation and trapped by 
      5,5-dimethyl-l-pyrroline-N oxide (DMPO). Ginseng extracts scavenged 40% of 
      hydroxyl radical at 0.1 mg/ml. Two mg/ml ginseng extracts completely scavenged 
      superoxide radical. Ginseng extracts did not scavenge nitric oxide. The ESR data 
      demonstrate that red ginseng aqueous extract is not a strong free radical 
      scavenger.
FAU - Kim, Yoo K
AU  - Kim YK
AD  - Department of Molecular and Cell Biology, University of California, Berkeley, CA 
      94720-3200, USA.
FAU - Guo, Qiong
AU  - Guo Q
FAU - Packer, Lester
AU  - Packer L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Free Radicals)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Picrates)
RN  - 0 (Plant Extracts)
RN  - 11062-77-4 (Superoxides)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 3352-57-6 (Hydroxyl Radical)
RN  - 755BO701MA (Bepridil)
RN  - DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
SB  - IM
MH  - Bepridil/*analogs & derivatives/chemistry
MH  - Biphenyl Compounds
MH  - Electron Spin Resonance Spectroscopy
MH  - Free Radical Scavengers/*chemistry
MH  - Free Radicals/chemistry
MH  - Hydroxyl Radical/chemistry
MH  - Indicators and Reagents
MH  - Nitric Oxide/chemistry
MH  - Panax/*chemistry
MH  - *Picrates
MH  - Plant Extracts/chemistry
MH  - Superoxides/chemistry
EDAT- 2002/03/08 10:00
MHDA- 2002/04/19 10:01
CRDT- 2002/03/08 10:00
PHST- 2002/03/08 10:00 [pubmed]
PHST- 2002/04/19 10:01 [medline]
PHST- 2002/03/08 10:00 [entrez]
AID - S0300483X01005856 [pii]
AID - 10.1016/s0300-483x(01)00585-6 [doi]
PST - ppublish
SO  - Toxicology. 2002 Mar 20;172(2):149-56. doi: 10.1016/s0300-483x(01)00585-6.