PMID- 11883436
OWN - NLM
STAT- MEDLINE
DCOM- 20020821
LR  - 20191105
IS  - 0381-6605 (Print)
IS  - 0381-6605 (Linking)
VI  - 31
IP  - 1
DP  - 2002 Feb
TI  - Genetic basis of familial Meniere's disease.
PG  - 1-4
AB  - The genetic basis of familial Meniere's disease (MD) is unclear. We present a 
      genetic investigation of six individuals in two families with familial MD. 
      Linkage analysis was performed using polymorphic DNA markers linked to the human 
      leukocyte antigen (HLA) locus that map to chromosome 6p. We have demonstrated the 
      presence of anticipation in successive generations and the absence of HLA 
      association. This is the second report of anticipation in familial MD in the 
      literature, and it suggests that efforts should be directed toward finding a 
      trinucleotide expansion as a possible genetic lesion in this uncommon disorder.
FAU - Fung, Kevin
AU  - Fung K
AD  - Department of Otolaryngology, London Health Sciences Centre, University of 
      Western Ontario, London.
FAU - Xie, Y
AU  - Xie Y
FAU - Hall, Stephen F
AU  - Hall SF
FAU - Lillicrap, David P
AU  - Lillicrap DP
FAU - Taylor, Sherryl A M
AU  - Taylor SA
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Otolaryngol
JT  - The Journal of otolaryngology
JID - 7610513
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - *Anticipation, Genetic
MH  - Female
MH  - Genetic Linkage/*genetics
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Male
MH  - Meniere Disease/*genetics
MH  - Middle Aged
MH  - Pedigree
MH  - Polymorphism, Genetic/genetics
MH  - Severity of Illness Index
MH  - Trinucleotide Repeat Expansion/genetics
EDAT- 2002/03/09 10:00
MHDA- 2002/08/22 10:01
CRDT- 2002/03/09 10:00
PHST- 2002/03/09 10:00 [pubmed]
PHST- 2002/08/22 10:01 [medline]
PHST- 2002/03/09 10:00 [entrez]
AID - 10.2310/7070.2002.19261 [doi]
PST - ppublish
SO  - J Otolaryngol. 2002 Feb;31(1):1-4. doi: 10.2310/7070.2002.19261.