PMID- 11883701
OWN - NLM
STAT- MEDLINE
DCOM- 20020321
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 70
IP  - 11
DP  - 2002 Feb 1
TI  - Interleukin-18 reduces expression of cardiac tumor necrosis factor-alpha and 
      atrial natriuretic peptide in a murine model of viral myocarditis.
PG  - 1225-34
AB  - Heart failure is generally believed to begin with myocyte damage caused by a 
      variety of insults, including ischemia, toxin or myocardial infection. The 
      proinflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), has been 
      hypothesized to play a pathogenetic role in the transition from compensated to 
      decompensated heart failure. Interleukin-18 (IL-18), a recently cloned cytokine 
      synthesized by Kupffer cells, activates macrophages. We examined the therapeutic 
      effect of IL-18 on the modulation of TNF-alpha gene expression in failing heart 
      in a murine model of heart failure caused by viral myocarditis. The heart weight 
      (HW)/ body weight (BW) ratio in IL-18 treated mice 7 days after viral inoculation 
      was significantly lower (P<0.01) than in the untreated controls. Myocardial 
      necrosis and inflammatory cell infiltration were significantly lower in IL-18 
      treated mice than untreated mice 5 and 7 days after inoculation. The expression 
      of TNF-alpha mRNA in the myocardium was significantly lower on days 5 and 7 in 
      IL-18 treated mice than in infected untreated mice. We conclude that concurrent 
      systemic administration of IL-18 is beneficial in mice with myocarditis, and may 
      be mediated through reduced expression of TNF-alpha in the heart.
FAU - Yoshida, Akihiro
AU  - Yoshida A
AD  - Department of Laboratory Medicine Gunma University School of Medicine, Maebashi, 
      Japan.
FAU - Kand, Tsugiyasu
AU  - Kand T
FAU - Tanaka, Toru
AU  - Tanaka T
FAU - Yokoyama, Tomoyuki
AU  - Yokoyama T
FAU - Kurimoto, Masashi
AU  - Kurimoto M
FAU - Tamura, Junichi
AU  - Tamura J
FAU - Kobayashi, Isao
AU  - Kobayashi I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Interleukin-18)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 63231-63-0 (RNA)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Animals
MH  - Atrial Natriuretic Factor/*biosynthesis/genetics
MH  - Disease Models, Animal
MH  - Female
MH  - Heart/drug effects
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Interleukin-18/*therapeutic use
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Myocarditis/*drug therapy/pathology/virology
MH  - Myocardium/chemistry/*metabolism/pathology
MH  - Necrosis
MH  - Organ Size/drug effects
MH  - RNA/isolation & purification
MH  - RNA, Messenger/metabolism
MH  - Tumor Necrosis Factor-alpha/analysis/*biosynthesis
EDAT- 2002/03/09 10:00
MHDA- 2002/03/22 10:01
CRDT- 2002/03/09 10:00
PHST- 2002/03/09 10:00 [pubmed]
PHST- 2002/03/22 10:01 [medline]
PHST- 2002/03/09 10:00 [entrez]
AID - S0024-3205(01)01509-0 [pii]
AID - 10.1016/s0024-3205(01)01509-0 [doi]
PST - ppublish
SO  - Life Sci. 2002 Feb 1;70(11):1225-34. doi: 10.1016/s0024-3205(01)01509-0.