PMID- 11885025
OWN - NLM
STAT- MEDLINE
DCOM- 20020913
LR  - 20060307
IS  - 0094-6176 (Print)
IS  - 0094-6176 (Linking)
VI  - 28
IP  - 1
DP  - 2002 Feb
TI  - Anticoagulants in thrombosis and cancer: the missing link.
PG  - 45-52
AB  - Many cancer patients reportedly have a hypercoagulable state, with recurrent 
      thrombosis due to the impact of cancer cells and chemotherapy on the coagulation 
      cascade. Studies have demonstrated that unfractionated heparin (UFH) or 
      low-molecular-weight heparin (LMWH) interferes with various processes involved in 
      tumor growth and metastasis. These processes might include fibrin formation, 
      binding of heparin to angiogenic growth factors such as basic fibroblast growth 
      factor and vascular endothelial growth factor, modulation of tissue factor, and 
      other mechanisms. Clinical trials have indicated a clinically relevant effect of 
      LMWH as compared with UFH on the survival of cancer patients with deep vein 
      thrombosis. Similarly, the impact of warfarin on the survival of cancer patients 
      with thromboembolic disorders was demonstrated. Recent studies from our 
      laboratory defined the role of an LMWH (tinzaparin), warfarin, anti-factor VIIa, 
      and recombinant tissue factor pathway inhibitor in the modulation of 
      angiogenesis, tumor growth, and tumor metastasis.
FAU - Mousa, Shaker A
AU  - Mousa SA
AD  - Albany College of Pharmacy, Albany, New York, USA. mousa@dnamail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Thromb Hemost
JT  - Seminars in thrombosis and hemostasis
JID - 0431155
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Animals
MH  - Anticoagulants/*therapeutic use
MH  - Humans
MH  - Neoplasm Metastasis/drug therapy/prevention & control
MH  - Neoplasms/blood/complications/*drug therapy
MH  - Neovascularization, Pathologic/drug therapy/prevention & control
MH  - Thrombosis/*drug therapy/etiology
RF  - 51
EDAT- 2002/03/09 10:00
MHDA- 2002/09/14 10:01
CRDT- 2002/03/09 10:00
PHST- 2002/03/09 10:00 [pubmed]
PHST- 2002/09/14 10:01 [medline]
PHST- 2002/03/09 10:00 [entrez]
AID - 10.1055/s-2002-20559 [doi]
PST - ppublish
SO  - Semin Thromb Hemost. 2002 Feb;28(1):45-52. doi: 10.1055/s-2002-20559.