PMID- 11885028
OWN - NLM
STAT- MEDLINE
DCOM- 20020913
LR  - 20071115
IS  - 0094-6176 (Print)
IS  - 0094-6176 (Linking)
VI  - 28
IP  - 1
DP  - 2002 Feb
TI  - Improved cancer mortality with low-molecular-weight heparin treatment: a review 
      of the evidence.
PG  - 79-87
AB  - Work with low-molecular-weight heparins (LMWHs) continues to provide suggestions 
      for survival advantages among patients with cancer diagnoses. Momentum is 
      building in support of this theory through reports, the vast majority of which 
      are derived from secondary analyses of clinical trials on the treatment of 
      thromboembolism. The data retrieved from such studies that compare unfractionated 
      heparin (UFH) with LMWH indicate that LMWH is equally beneficial if not more 
      beneficial to cancer patients in terms of survival. In retrospective analysis, 
      this improved life expectancy is not considered a result of reduced complications 
      from thromboembolism. Thus, theories of antitumor effects of LMWH have developed, 
      supported by evidence that most of the survival benefits are during long-term 
      comparisons. Reports describing the effects of heparin in the setting of cancer 
      have existed for over a half-century, although specific mechanisms for the 
      marginal results seen thus far have yet to surface. Proposals for the most likely 
      targets of the effective heparins include enzyme interaction, cellular growth 
      modifications, and antiangiogenesis.
FAU - Cosgrove, Richard H
AU  - Cosgrove RH
AD  - Department of Pharmacy, Harper University Hospital, Detroit Medical Center, 
      Detroit, Michigan 48201, USA. r_cosgrove@hotmail.com
FAU - Zacharski, Leo R
AU  - Zacharski LR
FAU - Racine, Eric
AU  - Racine E
FAU - Andersen, Judith C
AU  - Andersen JC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Thromb Hemost
JT  - Seminars in thrombosis and hemostasis
JID - 0431155
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Heparin/administration & dosage/pharmacology/therapeutic use
MH  - Heparin, Low-Molecular-Weight/administration & dosage/pharmacology/*therapeutic 
      use
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - Neoplasms/*drug therapy/*mortality
MH  - Survival Rate
RF  - 76
EDAT- 2002/03/09 10:00
MHDA- 2002/09/14 10:01
CRDT- 2002/03/09 10:00
PHST- 2002/03/09 10:00 [pubmed]
PHST- 2002/09/14 10:01 [medline]
PHST- 2002/03/09 10:00 [entrez]
AID - 10.1055/s-2002-20566 [doi]
PST - ppublish
SO  - Semin Thromb Hemost. 2002 Feb;28(1):79-87. doi: 10.1055/s-2002-20566.