PMID- 11886476
OWN - NLM
STAT- MEDLINE
DCOM- 20020517
LR  - 20191105
IS  - 1083-4389 (Print)
IS  - 1083-4389 (Linking)
VI  - 7
IP  - 1
DP  - 2002 Feb
TI  - The presence of immunoglobulins in the gastric juice of patients infected with 
      Helicobacter pylori is related to a reduced secretion of acid.
PG  - 67-70
AB  - BACKGROUND: It has been reported that treatment with proton pump inhibitors (PPI) 
      leads to partial elimination and suppression of Helicobacter pylori. In theory, 
      since acid is known to denature immunoglobulins, this antibacterial activity of 
      PPI may be due to a reduction in the acid output favouring humoral immunity. 
      MATERIALS AND METHODS: We analysed prospectively fasting gastric juice in 54 
      consecutive patients attending upper endoscopy for pH and levels of IgG, IgA and 
      IgM. In addition, two antral and two corpus biopsies were obtained and 
      histologically examined for the presence of H. pylori. RESULTS: 41/54 patients 
      were infected with H. pylori. Immunoglobulines in the gastric juice of these 
      patients were found in 25/41 (IgG), 27/41 (IgA), and 29/41 (IgM) patients. There 
      was a highly significant difference in the gastric pH when H. pylori infected 
      patients with measurable IgG, IgA, or IgM were compared with those in whom no 
      immunoglobulines were found (median pH: 6 vs. 2 in each group; p <.001) 
      CONCLUSIONS: There is a close correlation between a high gastric pH and the 
      presence of IgG, IgA, and IgM antibodies. Hence, it may be speculated that the 
      efficacy of humoral immunity following H. pylori infection depends on a high pH 
      such as resulting from PPI treatment.
FAU - Meining, Alexander
AU  - Meining A
AD  - Department of Medicine II, Klinikum rechts der Isar, Technical University of 
      Munich, Germany.
FAU - Wick, Manfred
AU  - Wick M
FAU - Miehlke, Stephan
AU  - Miehlke S
FAU - Bayerdorffer, Ekkehard
AU  - Bayerdorffer E
FAU - Stolte, Manfred
AU  - Stolte M
FAU - Sackmann, Michael
AU  - Sackmann M
FAU - Ochsenkuhn, Thomas
AU  - Ochsenkuhn T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Helicobacter
JT  - Helicobacter
JID - 9605411
RN  - 0 (Immunoglobulins)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gastric Acid/*metabolism
MH  - Gastric Juice/*immunology
MH  - Helicobacter Infections/drug therapy/*immunology/microbiology
MH  - Helicobacter pylori/*immunology
MH  - Humans
MH  - Immunoglobulins/*analysis
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors
EDAT- 2002/03/12 10:00
MHDA- 2002/05/23 10:01
CRDT- 2002/03/12 10:00
PHST- 2002/03/12 10:00 [pubmed]
PHST- 2002/05/23 10:01 [medline]
PHST- 2002/03/12 10:00 [entrez]
AID - 058 [pii]
AID - 10.1046/j.1523-5378.2002.00058.x [doi]
PST - ppublish
SO  - Helicobacter. 2002 Feb;7(1):67-70. doi: 10.1046/j.1523-5378.2002.00058.x.