PMID- 11888524
OWN - NLM
STAT- MEDLINE
DCOM- 20020514
LR  - 20190718
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 161
IP  - 2
DP  - 2002 Apr
TI  - Increased levels of monocyte-related cytokines in patients with unstable angina.
PG  - 403-8
AB  - Inflammatory cytokines play important roles in coronary artery disease. We 
      investigated the clinical significance of monocyte-related cytokine expression in 
      patients with angina pectoris. We studied 26 patients with stable effort angina 
      and 20 patients with unstable angina in whom stenotic lesions of the coronary 
      arteries were confirmed by selective coronary angiography. Plasma levels of 
      interleukin-6 (IL-6), macrophage colony stimulating factor (MCSF), and monocyte 
      chemoattractant protein-1 (MCP-1) were measured. Plasma levels of IL-6, MCSF, and 
      MCP-1 in patients with unstable angina were significantly higher than those in 
      patients with stable angina or control subjects. Patients with unstable angina 
      were further divided into sub-groups according to their clinical classification; 
      Levels of IL-6, MCSF, and MCP-1 in patients, who had anginal attacks at rest 
      within the 48 h prior to admission (Braunwald class IIIB) were significantly 
      higher than those in patients, who did not have attacks at rest (class IB). Five 
      unstable patients, who were refractory to medical therapy and were referred for 
      emergency coronary revascularization showed marked elevation of plasma MCSF and 
      MCP-1 levels. In conclusion, plasma levels of monocyte-related cytokines were 
      elevated in unstable angina. These increases were marked in patients with 
      unstable angina with recent ischemic attack at rest, suggesting that activation 
      of monocytes is involved in vulnerability of underlying atheromatous plaque.
FAU - Hojo, Yukihiro
AU  - Hojo Y
AD  - Department of Cardiology, Jichi Medical School, Minamikawachi-machi, Tochigi 
      329-0498, Japan.
FAU - Ikeda, Uichi
AU  - Ikeda U
FAU - Takahashi, Masafumi
AU  - Takahashi M
FAU - Shimada, Kazuyuki
AU  - Shimada K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Angina, Unstable/*blood/*physiopathology
MH  - Biomarkers/blood
MH  - Cardiac Catheterization
MH  - Chemokine CCL2/analysis
MH  - Cytokines/*analysis/*biosynthesis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interleukin-6/analysis
MH  - Macrophage Colony-Stimulating Factor/analysis
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*metabolism
MH  - Probability
MH  - Prognosis
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2002/03/13 10:00
MHDA- 2002/05/15 10:01
CRDT- 2002/03/13 10:00
PHST- 2002/03/13 10:00 [pubmed]
PHST- 2002/05/15 10:01 [medline]
PHST- 2002/03/13 10:00 [entrez]
AID - S0021-9150(01)00636-0 [pii]
AID - 10.1016/s0021-9150(01)00636-0 [doi]
PST - ppublish
SO  - Atherosclerosis. 2002 Apr;161(2):403-8. doi: 10.1016/s0021-9150(01)00636-0.