PMID- 11890512
OWN - NLM
STAT- MEDLINE
DCOM- 20020409
LR  - 20191105
IS  - 0955-9930 (Print)
IS  - 0955-9930 (Linking)
VI  - 13
IP  - 5
DP  - 2001 Oct
TI  - Assessment of the efficacy and safety of Viagra (sildenafil citrate) in men with 
      erectile dysfunction during long-term treatment.
PG  - 261-7
AB  - Long-term efficacy and safety of sildenafil was assessed in 1008 patients with 
      erectile dysfunction (ED) enrolled in four flexible-dose (25 - 100 mg), 
      open-label, 36- or 52-week extension studies. After 36 and 52 weeks, 92% and 89% 
      of patients felt that treatment with sildenafil had improved their erections. 
      Responses to a Sexual Function Questionnaire indicated that 52 weeks of 
      sildenafil treatment resulted in clinically significant improvements in the 
      duration and firmness of erections, overall satisfaction with sex life, and the 
      frequency of stimulated erections. Commonly reported adverse events (AEs) were 
      headache, flushing, dyspepsia, and rhinitis, which were generally mild to 
      moderate. Reports of abnormal vision were consistent with previous clinical 
      trials. The occurrence of treatment-related cardiovascular AEs, such as 
      hypertension, tachycardia, and palpitation, was <1%. Discontinuations due to 
      treatment-related AEs were low (2%). Long-term therapy does not diminish the 
      efficacy of sildenafil in patients with ED and remains well tolerated.
FAU - Steers, W
AU  - Steers W
AD  - Department of Urology, University of Virginia Hospital West, Charlottesville 
      22908, USA.
FAU - Guay, A T
AU  - Guay AT
FAU - Leriche, A
AU  - Leriche A
FAU - Gingell, C
AU  - Gingell C
FAU - Hargreave, T B
AU  - Hargreave TB
FAU - Wright, P J
AU  - Wright PJ
FAU - Price, D E
AU  - Price DE
FAU - Feldman, R A
AU  - Feldman RA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Impot Res
JT  - International journal of impotence research
JID - 9007383
RN  - 0 (Piperazines)
RN  - 0 (Purines)
RN  - 0 (Sulfones)
RN  - BW9B0ZE037 (Sildenafil Citrate)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Erectile Dysfunction/*drug therapy/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Penile Erection/drug effects
MH  - Piperazines/administration & dosage/adverse effects/*therapeutic use
MH  - Purines
MH  - Safety
MH  - Sex
MH  - Sildenafil Citrate
MH  - Sulfones
MH  - Surveys and Questionnaires
EDAT- 2002/03/14 10:00
MHDA- 2002/04/10 10:01
CRDT- 2002/03/14 10:00
PHST- 2002/03/14 10:00 [pubmed]
PHST- 2002/04/10 10:01 [medline]
PHST- 2002/03/14 10:00 [entrez]
AID - 10.1038/sj.ijir.3900714 [doi]
PST - ppublish
SO  - Int J Impot Res. 2001 Oct;13(5):261-7. doi: 10.1038/sj.ijir.3900714.